Sarcoplasmic Reticular Control of Cardiac Contraction and Relaxation

  • Arnold M. Katz


Any analysis of cardiac relaxation requires an understanding of the role of the sarcoplasmic reticulum (SR) in removing activator Ca2+ from the cytosol at the end of systole. The precise relationship between Ca2+ uptake into this intracellular membrane system and the changes in muscle length and tension that occur during diastole remains incompletely understood, but it is generally accepted that relaxation begins when cytosolic Ca2+ is reduced by the calcium pump of the SR.


Sarcoplasmic Reticulum Adenosine Triphosphatase Calcium Pump Allosteric Effect Sarcoplasmic Reticulum Membrane 
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  1. 1.
    Tada M, Yamamoto T, Tonomura Y (1978). Molecular mechanism of active calcium transport by sarcoplasmic reticulum. Physiol Rev 58: 1–79.PubMedGoogle Scholar
  2. 2.
    Martin DW, Tanford C (1981). Phosphorylation of calcium adenosine triphosphatase by inorganic phosphate: van’t Hoff analysis of enthalpy changes. Biochem 20: 4597–4602.CrossRefGoogle Scholar
  3. 3.
    Inesi G (1981). The sarcoplasmic reticulum of skeletal and cardiac muscle. In Dowben RM, Shay JW (eds): Cell and Muscle Motility. Plenum, New York: 63–97.Google Scholar
  4. 4.
    Ikemoto N (1982). Structure and function of the calcium pump protein of sarcoplasmic reticulum. Annu Rev Physiol 44: 297–317.PubMedCrossRefGoogle Scholar
  5. 5.
    Shigekawa M, Wakabayashi S, Nakamura H (1983). Reaction mechanism of Ca2+-dependent adenosine triphosphatase of sarcoplasmic reticulum. J Biol Chem 258: 8698–8707.PubMedGoogle Scholar
  6. 6.
    Tada M, Katz AM (1982). Phosphorylation of the sarcoplasmic reticulum and sarcolemma: Annu Rev Physiol 44: 401–423.PubMedGoogle Scholar
  7. 7.
    Katz AM, Takenaka H, Watras J (1986). The sarcoplasmic reticulum. In Fozzard H, et al (eds): The Heart and Cardiovascular System. New York: Raven Press.Google Scholar
  8. 8.
    Endo M (1977). Calcium release from the sarcoplasmic reticulum. Physiol Rev 57: 7 1108.Google Scholar
  9. 9.
    Fabiato A (1983). Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol 245: C1 - C14.PubMedGoogle Scholar
  10. 10.
    Somlyo AV,•Gonzalez-Serratos H, McClellan G, Somlyo AP (1981). Calcium release and ionic changes in the sarcoplasmic reticulum of tetanized muscle: An electron-probe study. J Cell Biol 90: 577–594.Google Scholar
  11. 11.
    Martonosi A (1984). Mechanisms of Ca2+ release from sarcoplasmic reticulum of skeletal muscle. Physiol Rev 64: 1240–1320.PubMedGoogle Scholar
  12. 12.
    Katz AM, Repke DI, Fudyma G, Shigekawa M (1977). Control of calcium efflux from sarcoplasmic reticulum vesicles by external calcium. J Biol Chem 252: 4210–4212.PubMedGoogle Scholar
  13. 13.
    Fleischer S, Ogunbunmi EM, Dixon MC, Fleer EAM (1985). Localization of Ca2+ release channels with ryanodine in junctional terminal cisternae of sarcoplasmic reticulum of fast skeletal muscle. Proc Acad Sci USA 82: 72567259.Google Scholar
  14. 14.
    Tsien RW (1983). Calcium channels in excitable cell membranes. Annu Rev Physiol 45: 341–358.PubMedCrossRefGoogle Scholar
  15. 15.
    Shigekawa M, Finegan J-AM, Katz AM (1976). Calcium transport ATPase of canine cardiac. sarcoplasmic reticulum: A comparison with that of rabbit fast skeletal muscle sarcoplasmic reticulum. J Biol Chem 251: 68946900.Google Scholar
  16. 16.
    Smith V-E, Weisfeldt ML, Katz AM (1986) Relaxation and diastolic properties of the heart. In Fozzard H, et al (eds): The Heart and Cardiovascular System. New York: Raven Press.Google Scholar
  17. 17.
    Katz AM, Messineo FC, Nash-Adler P (1986). Effects of amphiphilic substances on sarcoplasmic reticulum function. In Entman ML, Van Winkle WB: Sarcoplasmic Reticulum in Muscle Physiology, vol II. Boca Raton, FL: CRC Press, pp 123–139.Google Scholar

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© Martinus Nijhoff Publishing 1987

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  • Arnold M. Katz

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