Sarcoplasmic Reticular Control of Cardiac Contraction and Relaxation
Any analysis of cardiac relaxation requires an understanding of the role of the sarcoplasmic reticulum (SR) in removing activator Ca2+ from the cytosol at the end of systole. The precise relationship between Ca2+ uptake into this intracellular membrane system and the changes in muscle length and tension that occur during diastole remains incompletely understood, but it is generally accepted that relaxation begins when cytosolic Ca2+ is reduced by the calcium pump of the SR.
KeywordsSarcoplasmic Reticulum Adenosine Triphosphatase Calcium Pump Allosteric Effect Sarcoplasmic Reticulum Membrane
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- 3.Inesi G (1981). The sarcoplasmic reticulum of skeletal and cardiac muscle. In Dowben RM, Shay JW (eds): Cell and Muscle Motility. Plenum, New York: 63–97.Google Scholar
- 7.Katz AM, Takenaka H, Watras J (1986). The sarcoplasmic reticulum. In Fozzard H, et al (eds): The Heart and Cardiovascular System. New York: Raven Press.Google Scholar
- 8.Endo M (1977). Calcium release from the sarcoplasmic reticulum. Physiol Rev 57: 7 1108.Google Scholar
- 10.Somlyo AV,•Gonzalez-Serratos H, McClellan G, Somlyo AP (1981). Calcium release and ionic changes in the sarcoplasmic reticulum of tetanized muscle: An electron-probe study. J Cell Biol 90: 577–594.Google Scholar
- 13.Fleischer S, Ogunbunmi EM, Dixon MC, Fleer EAM (1985). Localization of Ca2+ release channels with ryanodine in junctional terminal cisternae of sarcoplasmic reticulum of fast skeletal muscle. Proc Acad Sci USA 82: 72567259.Google Scholar
- 15.Shigekawa M, Finegan J-AM, Katz AM (1976). Calcium transport ATPase of canine cardiac. sarcoplasmic reticulum: A comparison with that of rabbit fast skeletal muscle sarcoplasmic reticulum. J Biol Chem 251: 68946900.Google Scholar
- 16.Smith V-E, Weisfeldt ML, Katz AM (1986) Relaxation and diastolic properties of the heart. In Fozzard H, et al (eds): The Heart and Cardiovascular System. New York: Raven Press.Google Scholar
- 17.Katz AM, Messineo FC, Nash-Adler P (1986). Effects of amphiphilic substances on sarcoplasmic reticulum function. In Entman ML, Van Winkle WB: Sarcoplasmic Reticulum in Muscle Physiology, vol II. Boca Raton, FL: CRC Press, pp 123–139.Google Scholar