Comparative Effects of Ischemia and Hypoxia on Ventricular Relaxation in Isolated Perfused Hearts

  • Carl S. Apstein
  • Laura F. Wexler
  • W. Mark Vogel
  • Ellen O. Weinberg
  • Joanne S. Ingwall


Many experimental studies of left ventricular diastolic properties have utilized isolated perfused hearts subjected to either global ischemia or hypoxia. The isolated perfused heart model (see Figure 18-1) has several advantages. The pericardium is removed and the right ventricle is vented; thus, any pericardial or right ventricular interaction effect on left ventricular diastolic relaxation [1–4] is eliminated. Because the imposed ischemic or hypoxic condition is globally distributed throughout the myocardium, regional or segmental differences in contractility are eliminated, thus negating the effects on relaxation of “strong and weak segments in series” [6–7]. For these reasons, the isolated perfused heart model assesses the diastolic properties of the left ventricular chamber consisting of myocytes, connective tissue elements, interstitial fluid, and coronary vasculature.


Coronary Flow Global Ischemia Adenosine Infusion Coronary Vasculature Balloon Volume 
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Copyright information

© Martinus Nijhoff Publishing 1987

Authors and Affiliations

  • Carl S. Apstein
  • Laura F. Wexler
  • W. Mark Vogel
  • Ellen O. Weinberg
  • Joanne S. Ingwall

There are no affiliations available

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