Diastolic Myocardial Mechanics and the Regulation of Cardiac Performance

  • J. Scott Rankin
  • J. William Gaynor
  • Michael P. Feneley
  • Donald D. Glower
  • John A. Spratt
  • George S. Tyson
  • George W. Maier
  • Craig O. Olsen
  • Thomas N. Skelton
  • Thomas M. Bashore


Over the past 15 years, the primary goal of our physiology laboratory has been to improve the understanding of basic myocardial function in both normal and diseased hearts. Very early in our studies, it became evident that existing descriptors of myocardial performance were deficient, and initial efforts were expended to develop basic models of ventricular geometry, diastolic properties, and systolic function. Later work has been directed toward applying these models to the study of pathophysiology in ischemic heart disease and chronic volume overload. Although this investigation is still in progress, enough information is currently available to provide insight into basic aspects of diastolic myocardial function, to propose several hypotheses on how the heart adapts to clinical heart disease, and to provide direction for future clinical investigation of myocardial mechanics in humans. This chapter will review these topics primarily through publications from our laboratory, each of which contains full references.


Ventricular Pressure Stroke Work Diastolic Property Ventricular Geometry Intact Heart 
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Copyright information

© Martinus Nijhoff Publishing 1987

Authors and Affiliations

  • J. Scott Rankin
  • J. William Gaynor
  • Michael P. Feneley
  • Donald D. Glower
  • John A. Spratt
  • George S. Tyson
  • George W. Maier
  • Craig O. Olsen
  • Thomas N. Skelton
  • Thomas M. Bashore

There are no affiliations available

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