Clastogenic Factors, A Link Between Chronic Inflammation and Carcinogenesis

  • Ingrid Emerit


Clastogenic factors (CF), also called chromosome breakage factors, were first described by radiobiologists in 1968 (for review see 1). It was noted that not only do therapeutically or accidentally irradiated persons show an increased frequency of chromosome breaks and rearrangements in their own cells, but the plasma of these persons contains chromosome damaging material able to induce chromosome damage after transfer into cell cultures. These CF were circulating in the blood stream of the irradiated persons even years after the irradiation event (2). Plasma from irradiated animals had a tumorigenic effect in rats (3), suggesting a role for CF in carcinogenesis.


Systemic Sclerosis Irradiate Animal Clastogenic Activity Bromophenacyl Bromide Chinese Hamster Lung Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    C. B. Faguet, S. M. Reichard and D. A. Welter, Radiation-induced clastogenic factors. Cancer Genet. Cytogenet. 12:73–83 (1984).CrossRefGoogle Scholar
  2. 2.
    D. Scott, The effect of irradiated plasma on normal human chromosomes and its relevance to the long-lived lymphocyte hypothesis. Cell Tissue Kinet. 2:295–305 (1969).Google Scholar
  3. 3.
    J. Souto, Tumour development in the rat induced by blood of irradiated animals. Nature 195:1317–1318 (1962).PubMedCrossRefGoogle Scholar
  4. 4.
    I. Emerit, A. Levy and E. Housset, Breakage factor in systemic sclerosis and protector effect of L-cysteine. Humangenetik 25:221–225 (1974).PubMedCrossRefGoogle Scholar
  5. 5.
    I. Emerit and A. M. Michelson, Chromosome instability in human and murine autoimmune diseases. Anticlastogenic effect of superoxide dismutase. Acta Physiol. Scand. 492 (Suppl.) 59–65 (1980).Google Scholar
  6. 6.
    I. Emerit and R. Marteau, Chromosome studies in 14 patients with disseminated sclerosis. Humangenetik 21:25–29 (1971).CrossRefGoogle Scholar
  7. 7.
    I. Emerit and A. M. Michelson, Chromosomal breakage in Crohn’s disease. In: Recent Advances in Crohn’s Disease (A. S. Pena, Ed.), pp. 225–230 Martinus Nighoff Publishers, The Hague, 1981.CrossRefGoogle Scholar
  8. 8.
    I. Emerit, Chromosome breakage factors: origin and possible significance. Progr. Mutat. Res. 4:61–74 (1982).Google Scholar
  9. 9.
    A. D. Roumm and T. A. Medsger, Cancer and systemic sclerosis. An epidemiologic study. Arthritis Rheum. 28:1336–1340 (1985).PubMedCrossRefGoogle Scholar
  10. 10.
    D. D. Weedon, R. G. Shorter, D. M. Ilstrup, K. A. Huizenga, and W. F. Taylor, Crohn’s disease and cancer. N. Engl. J. Med. 289:1099-1102 (1973).Google Scholar
  11. 11.
    I. Emerit and P. Cerutti, Tumor promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action. Nature (London) 293:144–146 (1981).CrossRefGoogle Scholar
  12. 12.
    I. Emerit, S. H. Kahn and P. Cerutti, Treatment of lymphocyte cultures with a hypoxanthine-xanthine oxidase system induces the formation of transferable clastogenic material. J. Free Radicals Biol. Med. 1:51–57 (1985).CrossRefGoogle Scholar
  13. 13.
    I. E. Fridovich and N. A. Porter, Oxidation of arachidonic acid in micelles by superoxide and hydrogen peroxide. J. Biol. Chem. 256:260–265 (1981).PubMedGoogle Scholar
  14. 14.
    H. Esterbauer, Aldehydic products of lipid peroxidation. In: Free Radicals, Lipid Peroxidation and Cancer (D. C. McBrien and T. F. Slater, Eds.), pp. 101–128. Academic Press, London, 1982.Google Scholar
  15. 15.
    I. Emerit, J. Feingold, A. Levy, E. Martin and E. Housset, Tumor incidence and development of autoimmune hemolytic anemia in two breeding lines of the NZB mouse strain that differ in chromosome breakage. J. Natl. Cancer Inst. 64:510–520 (1980).Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Ingrid Emerit
    • 1
  1. 1.Institute Biomedical des CordeliersUniversite Paris VI and CNRSParisFrance

Personalised recommendations