Clastogenic Factors, A Link Between Chronic Inflammation and Carcinogenesis
Clastogenic factors (CF), also called chromosome breakage factors, were first described by radiobiologists in 1968 (for review see 1). It was noted that not only do therapeutically or accidentally irradiated persons show an increased frequency of chromosome breaks and rearrangements in their own cells, but the plasma of these persons contains chromosome damaging material able to induce chromosome damage after transfer into cell cultures. These CF were circulating in the blood stream of the irradiated persons even years after the irradiation event (2). Plasma from irradiated animals had a tumorigenic effect in rats (3), suggesting a role for CF in carcinogenesis.
KeywordsSystemic Sclerosis Irradiate Animal Clastogenic Activity Bromophenacyl Bromide Chinese Hamster Lung Cell
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