Inhibition of Autoxidation by Vitamin E and Bilirubin

  • Mohammed Al-Sheikhly
  • Michael G. Simic


Antioxidants are known to have an anticarcinogenic effect1,2. Although they are capable of reducing the incidence of tumors induced by chemical carcinogens, their effect on radiation-induced tumors has not been clearly demonstrated3,4. The mechanism of the anticarcinogenic action of antioxidants is poorly understood, and despite numerous mechanistic studies of autoxidation processes and antioxidants in model systems, detailed reaction mechanisms under physiological conditions are still elusive. However, inhibition of free radical processes may be an important part of this activity.


Linoleic Acid Peroxy Radical Pulse Radiolysis Free Radical Process Detailed Reaction Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    L. Wattenberg and L.K.T. Lan, Phenolic antioxidants as protective agents in chemical carcinogenesis. Radioprotectors and Anticarcinogenesis, 1983 (O. F. Nygaard and M. G. Simic, Eds.) pp. 461–470, Academic Press, New York.Google Scholar
  2. 2.
    M. G. Simic and E.P.L. Hunter, Interaction of free radicals and antioxidants. Ibid, pp 449–460.Google Scholar
  3. 3.
    P. A. Cerutti and I. Emerit, Tumor promoter phorbol-myristate-acetate induces membrane-mediated chromorsomal damage. Ibid, pp 527–538.Google Scholar
  4. 4.
    W. Bors, M. Saran and D. Tait, Eds. Oxygen Radicals in Chemistry and Biology (1984), Walter Gruyter and Co., Berlin, New York.Google Scholar
  5. 5.
    P. A. Cerutti, Prooxidant states and tumor promotion. Science, 227, 375–381 (1985).PubMedCrossRefGoogle Scholar
  6. 6.
    J. K. Thomas, “The Chemistry of Excitation at Interfaces” (1984), American Chemical Society, Washington, D.C.Google Scholar
  7. 7.
    M. Al-Sheikhly and M.G. Simic, J. Phys. Chem. submitted.Google Scholar
  8. 8.
    E.P.L. Hunter, M. G. Simic and B. D. Michael, Use of an optical multichannel analyzer for recording absorption spectra of short-lived transients. Rev. Sci. Instru. 2199–2204 (1985).Google Scholar
  9. 9.
    J. Swallow, “Radiation Chemistry” (1973), John Wiley & Sons, London.Google Scholar
  10. 10.
    J. A. Howard and K. U. Ingold, Absolute rate constants for hydrocarbon autoxidation V. The hydroperoxy radical chain propagation and termination. Can. J. Chem. 785–792 (1966).Google Scholar
  11. 11.
    N. A. Isildar, M. N. Schuchmann, D. Schulte-Frohlinde, C. von Sonntag, Oxygen uptake in the radiolysis of aqueous solutions of nucleic acids and their constituents. Int. J. Radiat. Biol. 41, 525–533 (1982).CrossRefGoogle Scholar
  12. 12.
    R. Stocker, Y. Yamamoto, A. F. Monagh, A. N. Glazer, and B. N. Ames, Bilirubin is an antioxidant of possible physiological in importance. Science 235, 1043–1045 (1987).PubMedCrossRefGoogle Scholar
  13. 13.
    M. G. Simic, M. Z. Hoffman, and I. A. Taub, Association for Radiation Research, University of Newcastle upon Tyne, 6th-8th January 1976 Book of Abstracts.Google Scholar
  14. 14.
    M. G. Simic and E.P.L. Hunter, The reactivity of organic oxygen (oxy) radicals. Oxygen Radicals in Chemistry 1984 (W. Bors, M. Saran and D. Tait, Eds.) pp 109–121, Walter de Gruyter and Co., Berlin. New York.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Mohammed Al-Sheikhly
    • 1
  • Michael G. Simic
    • 1
  1. 1.Center for Radiation ResearchNational Bureau of StandardsGaithersburgUSA

Personalised recommendations