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Modulation of Glutathione Levels and Metabolism

  • Alton Meister

Abstract

Glutathione (L-γ-glutamyl-L-cysteinyl-glycine), a tripeptide present in substantial concentrations in virtually all mammalian cells, plays a variety of roles in catalysis, metabolism, transport, and in cellular protection. A review of glutathione metabolism was presented at the first International Conference on Radioprotectors and Anticarcinogens (1); see also (2–6). A summary of glutathione metabolism is presented in Fig. 1. Understanding of the biochemistry of glutathione has led to procedures by which cellular levels of glutathione may be decreased or increased; glutathione metabolism may be modulated in other ways by selective inhibition of certain enzymes.

Keywords

Glutathione Level Glutathione Metabolism Glutathione Depletion Glutathione Synthesis Glutathione Synthetase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Alton Meister
    • 1
  1. 1.Cornell University Medical CollegeNew YorkUSA

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