Inhibition of Genotoxicity by Diallyl Sulfide and Structural Analogues

  • Mark T. Goldberg


Higher plants contain an extensive array of biologically active chemicals, some of which are potent modifiers of chemical carcinogenesis (1). Specifically, some of these agents have been shown to be active in inhibiting the initiation stage of the carcinogenesis process (2). Members of the Allium genus, which include onions and garlic, are rich in sulfur-containing compounds. Among the major components of garlic oil are diallyl disulfide (DADS, 66%) and diallyl sulfide (DAS, 14%) (3). It has been previously shown that the latter agent, DAS, can inhibit 1,2-dimethylhydrazine-induced genotoxicity in the murine colonic epithelium (4) and cyclophosphamide-induced genotoxicity in the murine urothelium and hair follicles (5). Recently it has been shown that DAS can inhibit 1,2-dimethylhydrazine-induced colon tumorigenesis (6). The goal of this study was to determine the optimal time for the oral administration of DAS, prior to carcinogen treatment, and to determine the efficacy of other structurally analogous sulfur-containing compounds.


Dimethyl Sulfide Colonic Crypt Chemical Carcinogenesis Diallyl Disulfide Colon Tumorigenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    National Academy of Sciences, Diet, Nutrition and Cancer, pp. 358–370. National Academy Press, Washington, D.C., 1982.Google Scholar
  2. 2.
    H.L. Newmark, A hypothesis for dietary components as a blocking agent of chemical carcinogenesis, plant phenollcs and pyrrole pigments. Nutr. Cancer 58–70 (1984).Google Scholar
  3. 3.
    M.H. Brodnltz, J.V. Pascale, and L.V. Derslice, Flavor components of garlic exract. J. Agrlc. Food Chem. 19; 273–275 (1971).CrossRefGoogle Scholar
  4. 4.
    M.J. Wargovich and M.T. Goldberg, Diallyl sulfide: A naturally occurring thioether that inhibits carcinogen-Induced nuclear damage to colori epthelial cells in vivo. Mutat. Res. 143: 127–129 (1985).PubMedCrossRefGoogle Scholar
  5. 5.
    M.T. Goldberg and P.D. Josephy, Studies on the mechanism of action of diallyl sulfide, an inhibitor of the genotoxic effects of cyclophosphamide. Can. J. Physiol. Pharmacol. 65: 476–471 (1987).Google Scholar
  6. 6.
    M.J. Wargovich, Diallyl sulfide, a flavor components of garlic (Allium sativum) inhibits dimethylhydrazine-induced colon cancer. Carcinogenesis 8: 487–489 (1987)PubMedCrossRefGoogle Scholar
  7. 7.
    M.J. Wargovich, M.T. Golderg, H.L. Newark, and W.R. Bruce, Nuclear aberrations as a short-term test for genotoxicity to the colon: evaluation of nineteen agents in mice. J. Natl. Cancer Inst. 71: 133–137 (1983).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Mark T. Goldberg
    • 1
  1. 1.Department of Biomedical SciencesUniversity of GuelphGuelphCanada

Personalised recommendations