UVB Prevention of Mouse Skin Tumor Induction by the Initiation-Promotion Protocol

  • H. L. Gensler


Repeated exposure of mice to UVB (280 to 320 nm) radiation results in the development of a state of tumor-specific suppression that renders the host Incapable of mounting an effective immunological rejection response to antigenic determinants expressed by UV-induced skin tumor cells (1,2). In this system, normal mice can reject transplanted UV-induced tumor cells, whereas UV-treated mice cannot. The objective of this research was to determine if UVB irradiation influences mouse skin tumorigcnesis induced by an initiation-promotion protocol.


Mouse Skin Distant Skin Promotion Regimen Mouse Skin Tumor Mouse Skin Tumorigenesis 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • H. L. Gensler
    • 1
  1. 1.Department of Radiation Oncology and Cancer CenterUniversity of Arizona Health Sciences CenterTucsonUSA

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