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Tumor Promotion: A Problem of Differential Responses of Normal and Neoplastic Cells to Trophic Stimuli

  • Stuart H. Yuspa
  • Henry Hennings
  • Takashi Sako
  • George R. Pettit
  • John Hartley
  • Peter M. Blumberg

Abstract

Increased understanding of the tumor promotion phase of chemical carcinogenesis has resulted from the discovery of pure tumor promoting-agents and the development of animal models in which tumor promoters modify experimental carcinogenesis (1). Simultaneously, interest in this area of cancer research has been stimulated by epidemiological studies indicating that a promotion phase is important in the development of human cancer (2). Tumor promoters cause or allow the expression of the latent tumor phenotype induced in some cells by limited doses of carcinogens. Commonly, the model systems where tumor promotion plays an important role in neoplastic development are those involving epithelial tissues, in particular those composed of more than one cell type or cells in different states of maturation such as skin, breast and bronchus. As a classical model for carcinogenesis in a lining epithelium, mouse skin has provided most of the conceptual framework regarding the biology of tumor promotion (1,3).

Keywords

Phorbol Ester Benzoyl Peroxide Tumor Promotion Mouse Skin Mouse Keratinocytes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Stuart H. Yuspa
    • 1
  • Henry Hennings
    • 1
  • Takashi Sako
    • 1
  • George R. Pettit
    • 2
  • John Hartley
    • 3
  • Peter M. Blumberg
    • 1
  1. 1.Laboratory of Cellular Carcinogenesis and Tumor PromotionNational Cancer InstituteBethesdaUSA
  2. 2.Cancer Research Institute and Department of ChemistryArizona State UniversityTempeUSA
  3. 3.Department of ChemistryUniversity of Alberta EdmontonAlbertaCanada

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