Metabolic Protection Against Rapid Cell Death Induced by High Level DNA Damage

  • Nathan A. Berger
  • Sosamma J. Berger
  • Donna C. Sudar


In response to DNA damage, the cell initiates a series of enzymatic reactions designed to repair its genetic structure and restore its normal function. In some cases, the metabolic consequences of these reactions can so drastically perturb cellular homeostasis that they lead to cell death. It is important to understand these biochemical processes in order to design rational approaches to alter their course.


L1210 Cell Deoxyribonucleic Acid Synthesis Diphosphate Ribose MNNG Treatment Adenosine Diphosphate Ribose 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Nathan A. Berger
    • 1
  • Sosamma J. Berger
    • 1
  • Donna C. Sudar
    • 1
  1. 1.Hematology/Oncology Division Departments of Medicine and Biochemistry Ireland Cancer CenterUniversity Hospitals of Cleveland Case Western Reserve University School of MedicineClevelandUSA

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