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Programmed −1 Frameshifting in Eukaryotes

  • Philip J. Farabaugh
Chapter

Abstract

By far the most numerous and the most ubiquitous of frameshift sites are a class of −1 frameshift sites first described in metazoan retroviruses. These sites have been found in retroviruses,27,36,40, 41, 42, 43,56,59,63,64 coronaviruses, 5,17,18,25,35 arteriviruses,31,61 astroviruses,44,57,99 giardiaviruses,96 toroviruses,80 several plant viruses,4,47,62,73,103 Drosophila retrotransposons, 16,58,72,76 a virus-like element in yeast,20,37,92 a bacterial gene,3,30,89 bacteriophage genes13,14,24,54 and bacterial insertion sequences.26,50,71,75,77,82,94,95 Sequence comparison and molecular genetic analysis of many of these sites has identified a canonical structure for these frameshift sites. Their prevalence across such an evolutionarily diverse distribution argues that such sites have evolved several times, each time converging on a single simple solution.

Keywords

Feline Immunodeficiency Virus Infectious Bronchitis Virus Mouse Mammary Tumor Virus Rous Sarcoma Virus Ribosomal Frameshifting 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • Philip J. Farabaugh
    • 1
  1. 1.Department of Biological SciencesUniversity of Maryland Baltimore CountyBaltimoreUSA

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