Oxygen Transport to Tissue XVIII pp 429-435 | Cite as
Pulmonary Delivery of Human Protein C and Factor IX
Chapter
Abstract
Recent advances in structural elucidation of numerous natural peptides and proteins1, enhanced understanding of their role in several physiological processes, and the use of biotechnological techniques for their production have stimulated considerable interest in establishing peptides and proteins as therapeutic agents. A major problem, aside from proteolytic degradation and physical alteration of the protein molecule at the site of administration, is the slow rate of transport of macromolecules across membrane barriers into the systemic circulation.
Keywords
Mass Median Aerodynamic Diameter Side Stream Pulmonary Delivery Mass Median Aerodynamic Diameter Monosodium Phosphate
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References
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© Springer Science+Business Media New York 1997