Neurochemistry pp 1029-1034 | Cite as

CMP-Dependent Degradation of Platelet-Activating Factor (PAF) by Rat Brain Microsomes

  • Ermelinda Francescangeli
  • Serena Porcellati
  • Gianfrancesco Goracci
Chapter

Abstract

PAF (l-O-alkyl-2-acetyl-5-sn-glycero-3-phosphocholine) is a potent lipid mediator that, in the nervous tissue, participates to physiological phenomena as well as in those related to pathological events (1,2). For instance, PAF is involved in neurotransmission (3–6) and it has been recently proposed as a retrograde messenger in hippocampal longterm potentiation (7,8) and in memory formation (9). On the other hand, it has been also reported that PAF concentration increases during cerebral ischemia and convulsions (10,11) and that PAF antagonists reduce brain damage associated with these pathological conditions (12,13). Thus, it is of great importance to know of the mechanisms controlling the concentration of this lipid mediator in the nervous tissue and consequently the regulation of the enzymes involved in its synthesis and degradation.

Keywords

Nervous Tissue Ehrlich Ascites Cell Retrograde Messenger Remodel Pathway Phosphocholine Cytidylyltransferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Ermelinda Francescangeli
    • 1
  • Serena Porcellati
    • 1
  • Gianfrancesco Goracci
    • 1
  1. 1.Institute of Medical BiochemistryUniversity of PerugiaPerugiaItaly

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