Skeletal Muscle Function, Oxygenation and Biochemistry in an Endotoxemic Model of Sirs

  • Ellen Dailor Iannoli
  • Thomas E. J. Gayeski
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 428)

Abstract

Traditionally, “sepsis” refers to bacteremia leading to arteriolar vasodilatation and signs of generalized infection. Sepsis may progress to septic shock, often characterized by hypotension, classically explained as pooling of blood in the peripheral microcirculation.1 A similar clinical picture in patients with no laboratory evidence of infection has been called the “septic syndrome.”9 Many of the characteristics of sepsis and the septic syndrome are mediated by host inflammatory products. The more comprehensive title systemic inflammatory response syndrome (SIRS) encompasses both states as well as states with similar clinical characteristics such as burn injuries.16 The clinical signs of SIRS are fever, tachycardia, low systemic vascular resistance, tachypnea, and leukocytosis or leuk- openia. Organ dysfunction may ensue despite adequate cardiac output and arterial oxygen tension. When more than 2 organs are dysfunctional, the patient is said to have multiple organ dysfunction syndrome (MODS). In patients the development of MODS leads to high mortality and great expense. Understanding the pathophysiology of SIRS may lead to improved therapy, lower mortality and reduced cost.16

Keywords

Mean Arterial Blood Pressure Multiple Organ Dysfunction Syndrome Muscle Blood Flow Gracilis Muscle Skeletal Muscle Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Ellen Dailor Iannoli
    • 1
  • Thomas E. J. Gayeski
    • 1
  1. 1.Departments of Anesthesiology and Pharmacology and PhysiologySchool of Medicine and Dentistry University of RochesterRochesterUSA

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