Structure-Function Studies on PEDF

A Noninhibitory Serpin with Neurotrophic Activity
  • S. Patricia Becerra
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 425)


Pigment epithelium-derived factor (PEDF) is a neurotrophic factor. In vitro it induces neuronal differentiation of retinoblastoma cells and promotes survival of cerebellar granule cell neurons. By virtue of amino acid sequence homology PEDF is a unique serpin member.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • S. Patricia Becerra
    • 1
  1. 1.Laboratory of Retinal Cell and Molecular BiologyNational Eye Institute National Institutes of HealthBethesdaUSA

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