Advertisement

Local Angiotensin II and Myocardial Fibrosis

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 432)

Abstract

A wound healing response that eventuates in fibrous tissue formation appears at the site of myocardial infarction (MI). Fibrosis can also appear remote to the MI where it can cause an extensive structural remodeling of viable myocardium. Fibrosis, an abnormal increase in tissue collagen concentration, can adversely affect organ function.

Keywords

Angiotensin Convert Enzyme Inhibitor Myocardial Fibrosis Infarcted Heart Collagen Gene Expression Binding Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Gabbiani G., Hirschel B. J., Ryan G. B., Statkov P. R., and Majno G. Granulation tissue as a contractile organ. A study of structure and function. J. Exp. Med. 1972: 135: 719–734.PubMedCrossRefGoogle Scholar
  2. 2.
    Sun Y. and Weber K. T. Angiotensin-converting enzyme and wound healing in diverse tissues of the rat. J. Lab. Clin. Med. 1996: 127: 94–101.PubMedCrossRefGoogle Scholar
  3. 3.
    Sun Y. and Weber K. T. Angiotensin converting enzyme and myofibroblasts during tissue repair in the rat heart. J. Mol. Cell. Cardiol. 1996: 28: 851–858.PubMedCrossRefGoogle Scholar
  4. 4.
    Sun Y, Cleutjens J. P. M, Diaz-Arias A. A., and Weber K. T. Cardiac angiotensin converting enzyme and myocardial fibrosis in the rat. Cardiovasc. Res. 1994: 28: 1423–143.PubMedCrossRefGoogle Scholar
  5. 5.
    Cleutjens J. P. M., Verluyten M. J. A., Smits J. F. M., and Daemen M. J. A. P. Collagen remodeling after myocardial infarction in the rat heart. Am. J. Pathol. 1995: 147: 325–338.PubMedGoogle Scholar
  6. 6.
    Jugdutt B. I. and Amy R. W. M. Healing after myocardial infarction in the dog: changes in infarct hydroxyproline and topography. J. Am. Coll. Cardiol. 1986: 7: 91–102.PubMedCrossRefGoogle Scholar
  7. 7.
    Whittaker P., Boughner D. R. and Kloner R. A. Analysis of healing after myocardial infarction using polarized light microscopy. Am. J. Phthol. 1989: 134, 879–893.Google Scholar
  8. 8.
    Volders P.G.A., Willems I.E.M.G., Cleutjens J.P.M., Arends J.-W., Havenith M.G., and Daemen M.J.A.P. Interstitial collagen is increased in the non-infarcted human myocardium after myocardial infarction. J. Mol. Cell. Cardiol. 1993: 25: 1317–1323.PubMedCrossRefGoogle Scholar
  9. 9.
    Darby I., Skalli O., and Gabbiani G. α-Smooth muscle actin is transiently expressed by α-smooth muscle actin-positive cells in healing human myocardial scars. Am. J. Pathol. 1994: 145: 868–875.Google Scholar
  10. 10.
    Willems I. E. M. G., Havenith M. G., De Mey J. G. R., and Daemen M. J. A. P. The myofibroblasts during experimental wound healing. Lab. Invest. 1990: 63: 21–29.Google Scholar
  11. 11.
    Appleton I., Tomlinson A., Chander C. L., and Willoughby D. A. Effect of endothelin-1 on croton oil-induced granulation tissue in the rat. A pharmacologic and immunohistochemical study. Lab. Invest. 1992: 67: 703–710.PubMedGoogle Scholar
  12. 12.
    Desmouliere A., Geinoz A., Gabbiani F. and Gabbiani G. Transforming growth factor-βl induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiscent and growing cultured fibroblasts. J. Cell Biol. 1993: 122, 103–111.PubMedCrossRefGoogle Scholar
  13. 13.
    Johnston C. I. Biochemistry and pharmacology of the renin-angiotensin system. Drugs 1990: 39(suppl 1), 21–31.PubMedCrossRefGoogle Scholar
  14. 14.
    Sakaguchi K, Chai S. Y, Jackson B., Johnston C. I., Mendelsohn F. A. Inhibition of tissue angiotensin converting enzyme. Quantitation by autoradiography. Hypertension 1988: 11, 230–238PubMedCrossRefGoogle Scholar
  15. 15.
    Scheling P., Fischer H., Ganten D., Angiotensin and cell growth: a link to cardiovascular hypertrophy? Hypertension 1991: 9, 3–15.Google Scholar
  16. 16.
    Baker K. M., Aceto J. F., Angiotensin II stimulation of protein synthesis and cell growth in chick heart cells. Am. J. Physiol. 1990: 259, H610–H618.PubMedGoogle Scholar
  17. 17.
    Weber K.T., Sun Y., Katwa L.C. Connective tissue: a metabolic entity? J. Mol. Cell. Cardiol. 1995: 27, 107–120.PubMedCrossRefGoogle Scholar
  18. 18.
    Baker K. M. Booz G. W. Dostal D. E. Cardiac actions of angiotensin II: role of an intracardiac renin-angiotensin system. Annu. Rev. Physio. 1992: 54, 227–241.CrossRefGoogle Scholar
  19. 19.
    Yamada H., Fabris B., Allen A. M., Jackson B., Johnston C. I., and Mendelsohn F. A. O. Localization of angiotensin converting enzyme in rat heart. Circ. Res. 1991: 68: 141–149.PubMedCrossRefGoogle Scholar
  20. 20.
    Sun Y and Weber KT. Angiotensin II and aldosterone receptor binding in rat heart and kidney: response to chronic angiotensin II or aldosterone administration. J. Lab. Clin. Med. 1993:122.404–411.PubMedGoogle Scholar
  21. 21.
    Keeley F. W., Elmoselhi A., and Leenen F. H. H. Enalapril suppresses normal accumulation of elastin and collagen in cardiovascular tissues of growing rats. Am. J. Physiol. 1992: 262: H1013–H1021.PubMedGoogle Scholar
  22. 22.
    Sun Y. and Weber K. T. Angiotensin II receptor binding following myocardial infarction in the rat. Cardiovasc. Res. 1994: 28: 1623–1628.PubMedCrossRefGoogle Scholar
  23. 23.
    Hodsman G. P., Kohzuki M., Howes L. G., Sumithran E., Tsunoda K., and Johnston C. I. Neurohumoral responses to chronic myocardial infarction in rats. Circulation 1988: 78: 376–381.PubMedCrossRefGoogle Scholar
  24. 24.
    Sun Y. and Weber K. T. Cells expressing angiotensin II receptors in fibrous tissue of rat heart. Cardiovasc. Res. 1996:31:518–525.PubMedGoogle Scholar
  25. 25.
    Jugdutt B. I., Humen D. P., Khan M. I., and Schwarz-Michorowski B. L. Effect of left ventricular unloading with Captopril on remodeling and function during healing of anterior transmural myocardial infarction in the dog. Can. J. Cardiol. 1992: 8: 151–163.PubMedGoogle Scholar
  26. 26.
    de Carvalho Frimm C., Sun Y., and Weber K. T Angiotensin II receptor blockade and myocardial fibrosis following infarction in the rat heart. J. Lab. Clin. Med. in press.Google Scholar
  27. 27.
    Michel J.-B., Lattion A.-L., Salzmann J.-L., Cerol M. L., Philippe M., Camilleri J.-P., et al. Hormonal and cardiac effects of converting enzyme inhibition in rat myocardial infarction. Circ. Res. 1988: 62: 641–650.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Yao Sun
    • 1
  1. 1.Department of Internal MedicineUniversity of Missouri Health Sciences CenterColumbiaUSA

Personalised recommendations