Abstract
Hepatic ischemia/reperfusion is a common problem encountered under many clinical conditions, and it occurs in a variety of surgical procedures. Possible consequences include liver failure and/or multi-organ system failure, both of which have high rates of morbidity and mortality.1,2 Efforts to minimize the extent of injury incurred during the ischemic period or to maximize reparative process following ischemia have importance for survival.3 In vivo 31P-nuclear magnetic resonance (NMR) spectroscopy has been used to follow the response of hepatic high-energy phosphates during hepatic ischemia/reperfusion.4 It measures the continuous changes of hepatic adenosine triphosphate (ATP) levels and their metabolites, and is an effective tool to evaluate the serial data in the individual following drug treatment.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D.V. Feliciano, K.L. Mattox, G.L. Jordan, J.M. Burch, C.G. Bistondo, P.A. Cruse, Management of 1000 consecutive cases of hepatic trauma (1979-1984), Ann Surg. 204: 438 (1986).
M. Usami, K. Furuchi, H. Shiroiwa, Y. Saitoh, Effect of repeated portal-triad cross-clamping during partial hepatectomy on hepatic regeneration in normal and cirrhotic rats, J Surg Res. 57: 541 (1994).
M.G. Clemens, P.F. McDonagh, I.H. Chaudry, and A.E. Baue, Hepatic microcirculatory failure after ischemia and reperfusion: improvement with ATP-MgC12 treatment, Am J Physiol. 2481: H804 (1985).
C.R. Malloy, C.C. Cunningham, and G.K. Radda, The metabolic state of the rat liver in vivo measured by 31P NMR spectroscopy, J Biochem Biophys Acta 885: 9276 (1986).
W. Ertel, G. Singh, MH. Morrison, A. Ayala, IH. Chaudry, Chemically induced hypotention increases PGE2 release and depresses macrophage antigen presentation, Am J Physiol 264: R655 (1993).
S. Ogoshi, M. Iwasa, T. Yonezawa, and T. Tamiya, Effect of nucleotide and nucleoside mixture on rats given total parenteral nutrition after 70% hepatectomy, J Parenter Enterai Nutr. 9: 339 (1985).
H. Ohyanagi, S. Nishimatu, Y. Kanbara, M. Usami, and Y. Saitoh, Effect of nucleosides and a nucleotide on DNA and RNA syntheses by the salvage and de novo pathway in primary monolayer cultures of hepatocytes and hepatoma cells, J Parenter Enterai Nutr. 13: 51 (1989).
M. Usami, K. Furuchi, M. Ogino, H. Kasahara, T. Kanamaru, Y. Saitoh, H. Yokoyama, and S. Kano, The effect of a nucleotide-nucleoside solution on hepatic regeneration after partial hepatectomy in rats Nutr. 12: 797 (1996).
M. Usami, A. Iso, H. Kasahara, G. Kotani, S. Haji, T. Kanamaru, and Y. Saitoh, Effect of a parenteral nucleoside-nucleotide mixture on hepatic metabolism in partially hepatectomized cirrhotic rats, Nutr. 12: 436 (1996).
K. Satoh, T. Nakai, H. Kohri, and K. Ichihara, Limitation of stunning in dog myocardium by nucleoside and nucleotide mixture, OG-VI. Coron Artery Dis. 4: 1007 (1993).
S. Kano, T. Nakai, H. Kohri, and K. Ichihara, Effects of OG-VI, a nucleoside/nucleotide mixture, and its constituents on myocardial stunning in dogs. Coron Artery Dis. 6: 811 (1995).
Y. Okazaki, S. Kano, S. Ogoshi, and K. Ichihara, Effects of OG-VI, a nucleoside-nucleotide mixture, on ischemic myocardial metabolism in dogs. Coron Artery Dis. 8: 39 (1997).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Usami, M. et al. (1998). A Nucleotide and Nucleosides Mixture Solution Improves Recovery of Energy Metabolism after Hepatic Ischemia in Rats. In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_78
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5381-6_78
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7456-5
Online ISBN: 978-1-4615-5381-6
eBook Packages: Springer Book Archive