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Mycophenolic Acid Influences the Expression of ICAM-1 on Human Endothelial Cells

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Purine and Pyrimidine Metabolism in Man IX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 431))

Abstract

Mycophenolic acid (MPA) is a potent immunosuppressive agent, which selectively decreases the intracellular guanine nucleotide pools by inhibiting the inosine-5′-mono-phosphate dehydrogenase (IMP-DH) thereby suppressing the proliferation of rapidly proliferating cells e.g. alloantigen stimulated lymphocytes (1,2).

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References

  1. T.J. Franklin, J.M. Cook, The inhibition of nucleic acid synthesis by mycophenolic acid. Biochem. J. 113: 2515 (1969).

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Authors and Affiliations

  1. Department of Cardiothoracic Surgery, University of Vienna, Austria

    P. Bertalanffy, P. Dubsky, G. Seebacher, A. Griesmacher, G. Weigel & E. Wolner

Authors
  1. P. Bertalanffy
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  2. P. Dubsky
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  3. G. Seebacher
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  4. A. Griesmacher
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  5. G. Weigel
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  6. E. Wolner
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Editor information

Editors and Affiliations

  1. Emperor Franz Joseph Hospital, Vienna, Austria

    Andrea Griesmacher  & Mathias M. Müller  & 

  2. University of Vienna, Vienna, Austria

    Peter Chiba

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© 1998 Springer Science+Business Media New York

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Bertalanffy, P., Dubsky, P., Seebacher, G., Griesmacher, A., Weigel, G., Wolner, E. (1998). Mycophenolic Acid Influences the Expression of ICAM-1 on Human Endothelial Cells. In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_109

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  • DOI: https://doi.org/10.1007/978-1-4615-5381-6_109

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7456-5

  • Online ISBN: 978-1-4615-5381-6

  • eBook Packages: Springer Book Archive

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