The cdc18 protein initiates DNA replication in fission yeast

  • Hideo Nishitani
  • Paul Nurse
Chapter
Part of the Progress in Cell Cycle Research book series (PCCR)

Abstract

Recent work has demonstrated that cdc18p plays a crucial role in regulating the onset of S phase in fission yeast. cdc18p is a major product of START specific transcription and associates with ORC and MCM proteins which are required for the initiation of DNA replication. High expression of cdc18p induces continuing DNA synthesis and is thought to drive the assembly of initiation complexes. In addition to its role in bringing about DNA replication, cdc18p participates in the cell cycle checkpoint control linking S phase to START and mitosis. We propose that cdc18p is central to the molecular mechanism co-ordinating S phase and M phase in concert with changes in activity of the master cell cycle regulator, the cdc2 protein kinase.

Keywords

Fission Yeast Replication Origin Initiation Complex Origin Recognition Complex Checkpoint Control 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Hideo Nishitani
    • 1
  • Paul Nurse
    • 1
  1. 1.Imperial Cancer Research FundLondonUK

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