Activating and Inhibitory NK Cell Receptors

  • Lewis L. Lanier
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 452)

Abstract

Kärre and colleagues observed that tumors lacking H-2 molecules were more susceptible to NK cell-mediated lysis than tumors expressing class I and proposed a unique mechanism of immune surveillance for ‘missing self’ (1). The molecular mechanism responsible for this phenomenon has been defined by the identification of membrane receptors on NK cells that bind to MHC class I on potential target cells. While the NK cell receptors initiating a cell-mediated response against tumors or virus-infected cells are not yet understood, killing of certain target cells can be partially or totally inhibited if the cells express MHC class I molecules that engage inhibitory receptors on the NK cell. Surprisingly, four distinct types of NK cell receptors for MHC class I that inhibit NK cell-mediated cytotoxicity have been identified.

Keywords

Natural Killer Cell Major Histocompatibility Complex Class Major Histocompatibility Complex Molecule Human Natural Killer Cell Natural Killer Cell Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Lewis L. Lanier
    • 1
  1. 1.Department of ImmunobiologyDNAX Research InstitutePalo AltoUSA

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