The Role of Dendritic Cells in the Initiation of Host Resistance to Toxoplasma Gondii

  • Alan Sher
  • Sara Hieny
  • Hugues Charest
  • Tanya Scharton-Kersten
  • Carmen Collazo
  • Ronald N. Germain
  • Caetano Reis e Sousa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 452)


Intracellular bacteria and protozoa typically stimulate host responses dominated by Type 1 cytokine production and cell-mediated immune effector functions. While the probable role of these responses is to limit growth of the infecting pathogen, the basis of their preferential induction is poorly understood and poses a fundamental question in immunologic class selection(1).


Dendritic Cell Cell Area Toxoplasma Gondii Monocytic Cell Line Class Selection 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Alan Sher
    • 1
  • Sara Hieny
    • 1
  • Hugues Charest
    • 1
  • Tanya Scharton-Kersten
    • 1
  • Carmen Collazo
    • 1
  • Ronald N. Germain
    • 2
  • Caetano Reis e Sousa
    • 2
  1. 1.Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  2. 2.Laboratory of Immunology, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA

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