Antithrombogenic and Antiatherogenic Effects of Citrus Flavonoids

Contributions of Ralph C. Robbins
  • John A. Attaway
  • Béla S. Buslig
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 439)

Abstract

This presentation is intended to commemorate the life’s work of a singular individual, Dr. Ralph C. Robbins, who was a pioneer among researchers studying the health benefits of flavonoids, particularly flavonoids such as hesperidin, tangeretin, nobiletin and others which occur in citrus fruits. Dr. Robbins entered the field in 1960, a time when research on health effects of flavonoids seemed to raise more questions than answers. To put Dr. Robbins’ research in perspective, let us first look very briefly at the history of flavonoid research.

Keywords

Erythrocyte Sedimentation Rate Methoxyl Group Atherogenic Diet Erythrocyte Aggregation Antiatherogenic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Brooks, K. M.; Robbins, R. C. An in vitro Method for Determination of Degree of Intravascular Aggregation of Blood Cells. Lab. Invest., 1968, 19, 580–583.PubMedGoogle Scholar
  2. MacDowell, L. G., E. L. Moore and C. D. Atkins. Method of Preparing Full-Flavored Fruit Juice Concentrates, U.S. Patent No. 2,453,109 1948.Google Scholar
  3. Robbins, R. C. Relation of Blood Cell Aggregation to Capillary Resistance. Angiology 1966a, 17, 416–421.PubMedCrossRefGoogle Scholar
  4. Robbins, R. C. Intravascular Aggregation of the Cellular Elements of Blood in Rats Fed Thrombogenic or Atherogenic Regimens,. J. Atheroscler. Res., 1966b, 6, 467–473.PubMedCrossRefGoogle Scholar
  5. Robbins, R. C. Effect of Vitamin C and Flavonoids on Blood Cell Aggregation and Capillary Resistance. Internal. J. Vit. Nutr. Res., 1966c, 36, 10–15.Google Scholar
  6. Robbins, R. C. Effect of Flavonoids on Survival Time of Rats Fed Thrombogenic or Atherogenic Regimens. J. Atheroscler. Res., 1967, 7, 3–10.PubMedCrossRefGoogle Scholar
  7. Robbins, R. C. Effects of Phenyl Benzo-y-Pyrone Derivatives (Flavonoids) on Blood Cell Aggregation: Basis for a Concept of Mode of Action. Clin. Chem., 1971, 17, 433.PubMedGoogle Scholar
  8. Robbins, R. C. Effect of Methoxylated Flavones on Erythrocyte Aggregation and Sedimentation in Blood of Normal Subjects: Evidence of a Dietary Role for Flavonoids. Internal. J. Vit. Nutr. Res., 1973a, 43, 494–503.Google Scholar
  9. Robbins, R. C. In Vitro Effects of Penta-, Hexa-and Hepta-Methoxylated Flavones on Aggregation of Cells in Blood from Hospitalized Patients. J. Clin. Pharmacology, 1973b, 13, 271–275.Google Scholar
  10. Robbins, R. C. Specificities Between Blood Cell Adhesion in Human Diseases and Antiadhesive Action in vitro of Methoxylated Flavones. J. Clin. Pharmacology, 1973c, 13, 401–407.Google Scholar
  11. Robbins, R. C. Antithrombogenie Properties of a Hexamethoxylated Flavonoid. Atherosclerosis, 1973d, 18, 73–82.PubMedCrossRefGoogle Scholar
  12. Robbins, R. C. Action of Flavonoids on Blood Cells: Trimodal Action of Flavonoids Elucidates Their Inconsistent Physiologic Effects. Internal. J. Vit. Nutr. Res., 1974, 44, 203–216.Google Scholar
  13. Robbins, R. C. Action in Human Blood of Methoxylated Flavones which Confer Disease Resistance on Both Plants and Animals: Concept of a Dietary Conditioned Mechanism of Defense. Internal. J. Vit. Nutr. Res., 1975a, 45, 52–59.Google Scholar
  14. Robbins, R. C. Mechanism of Reversed Flavonoid Action on Blood Cells: Significance in Thromboembolism. Internal. J. Vit. Nutr. Res., 1975b, 45, 163–174.Google Scholar
  15. Robbins, R. C. Regulatory Action of Phenylbenzo-y-Pyrone Derivatives on Blood Constituents Affecting Rheology in Patients with Coronary Heart Disease (CHD). Internal. J. Vit. Nutr. Res., 1976, 46, 338–347.Google Scholar
  16. Robbins, R. C. Stabilization of Flow Properties of Blood with Phenylbenzo-γ-Pyrone Derivatives (Flavonoids). Internal. J. Vit. Nutr. Res., 1977, 47, 373–382.Google Scholar
  17. Robbins, R. C. Medical and Nutritional Aspects of Citrus Bioflavonoids. In Citrus Nutrition and Quality, Nagy, S.; Attaway, J. A. eds., 1980a, pp. 43–59, American Chemical Society, Symposium Series, ACS, Washington, DC.CrossRefGoogle Scholar
  18. Robbins, R. C. On Bioflavonoids: New Findings about a Remarkable Plant Defense against Disease and Its Dietary Transfer to Man. Executive Health 1980b, 16(12), 1–9.Google Scholar
  19. Robbins, R. C. Inhibition of Platelet Aggregation by Methoxylated Flavones Isolated from Citrus. Report to the Florida Department of Citrus, Lakeland, Florida 1982.Google Scholar
  20. Robbins, R. C. Flavones in Citrus Exhibit Antiadhesive Action on Platelets. Internal. J. Vit. Nutr. Res., 1988, 58, 418–421.Google Scholar
  21. Robbins, R. C; Hammer, R. H.; Simpson, C. F. Methoxylated Phenyl Benzo-γ-Pyrone Derivatives (Flavonoids) that Highly Inhibit Erythrocyte Aggregation. Clin. Chem., 1971, 17, 1109–1113.PubMedGoogle Scholar
  22. Robbins, R. C; Martin, F. G.; Roe, J. M. Ingestion of Grapefruit Lowers Elevated Hematocrits in Human Subjects. Internal J. Vit. Nutr. Res., 1988, 58, 414–417.Google Scholar
  23. Robbins, R. C; Morrison, L. M. Effect of Chondroitin Sulfate A and Flavonoids on Blood Cell Aggregation of Rats. Fed. Proc, 1968 27, 646 (Abstract).Google Scholar
  24. Rusznyák, S.; Szent-Györgyi, A. Vitamin P: Flavonols as vitamins. Nature 1936, 27, 138.Google Scholar
  25. Sokoloff, B.; Redd, J. B. The Story of Vitamin P. Citrus Industry 1948, 29(7).Google Scholar
  26. Sokoloff, B.; Redd, J. B. The Health Angle in the Consumption of Canned Orange Juice. Citrus Industry 1949, 30(5) 5–13.Google Scholar
  27. Sokoloff, B.; Redd, J. B.; Dutcher, R. Vitamin P Protection Against Radiation, Science 1950a, 112, 112–113.PubMedCrossRefGoogle Scholar
  28. Sokoloff, B.; Redd, J. B.; Dutcher, R. Capillary Fragility and Vitamin P Protection Against Radiation. Proc. Soc. Exp. Biol. Med., 1950b, 75, 6–9.PubMedGoogle Scholar
  29. Vickery, H. B.; Nelson, E. M.; Almquist, H. J.; Elvehjem, C. A. Term Vitamin P Recommended to be Discontinued. Science 1950, 112, 628.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • John A. Attaway
    • 1
    • 2
  • Béla S. Buslig
    • 1
    • 2
  1. 1.Florida Citrus Consultants International, Inc.Lake AlfredUSA
  2. 2.Florida Department of CitrusLake AlfredUSA

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