The Influence of Colony-Stimulating Factors on Neutrophil Production, Distribution, and Function

  • J. Milton Gaviria
  • W. Conrad Liles
  • David C. Dale
Part of the Developments in Oncology book series (DION, volume 80)


The colony-stimulating factors (ie. interleukin 3, granulocyte-macrophage colony-stimulating factor, granulocyte colony-stimulating factor and monocyte/macrophage colony stimulating factor) are a group of glycoproteins that regulate the proliferation and differentiation of hematopoietic precursor cells1–4. In addition to their effects on hematopoiesis, colony-stimulating factors (CSFs) modulate the function of fully mature cells and therefore play an important role in regulating inflammatory responses vital to host defense. Here we review recent information that describes the biological activity of CSFs, particularly focusing on their modulation of neutrophil production, distribution, and function. The spectrum of biological activity of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) is summarized in Table 1.


Human Neutrophil Neutrophil Apoptosis Mature Neutrophil Severe Congenital Neutropenia Neutrophil Respiratory Burst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • J. Milton Gaviria
  • W. Conrad Liles
  • David C. Dale

There are no affiliations available

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