The Role of The Neural Growth Associated Protein B-50/Gap-43 in Morphogenesis

  • L. H. J. Aarts
  • P. Schotman
  • J. Verhaagen
  • L. H. Schrama
  • W. H. Gispen

Abstract

Axonal guidance during development and regeneration can largely be attributed to a specialized structure at the distal end of a neurite called the growth cone (Ramon y Cajal, 1966). Structurally, these highly dynamic swellings can be divided into three distinct regions: a base, a central region and a peripheral region. The base is formed by the transition from growth cone to neurite, where bundles of microtubules diverge and extend into the central region. This region consists of a microtubular skeleton and is rich in membranous organelles such as mitochondria, dense and clear cored vesicles and endoplasmic reticu-lum like structures. The flattened leading edge of the growth cone, the peripheral region, is filled with a dense meshwork of actin filaments and is virtually devoid of microtubules and organelles. Growth cone and neurite architecture and motility are supported by a complex network of cell adhesion molecules, microtubules, actin, intermediate filaments and specific interacting regulatory proteins.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • L. H. J. Aarts
    • 1
  • P. Schotman
    • 1
  • J. Verhaagen
    • 3
  • L. H. Schrama
    • 1
  • W. H. Gispen
    • 2
  1. 1.Rudolf Magnus Institute for NeurosciencesLaboratory of Physiological ChemistryUSA
  2. 2.Department of Medical Pharmacology StratenumUniversiteitsweg 100The Netherlands
  3. 3.Netherlands Institute for Brain ResearchAmsterdamThe Netherlands

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