Peroxynitrite Reacts with Methemoglobin to Generate Globin-Bound Free Radical Species

Implications for Vascular Injury
  • Chris E. Cooper
  • Jaume Torres
  • Martyn A. Sharpe
  • Mike T. Wilson
  • Dimitri A. Svistunenko
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 454)


Reactive oxygen species been implicated in oxidative stress and vascular injury. These include the free radicals Superoxide (O2⋅)’ hydroxyl (OH⋅), peroxyl (LO2⋅) and alkoxyl (LO⋅) and the non-radicals hydrogen peroxide (H2O2), lipid peroxides and singlet oxygen. It was originally thought that the hydroxyl radical (OH⋅) was likely to be the most damaging species (1); however, this free radical is so reactive that it has a diffusion distance of no more than a few nm at most (2). The hydroxyl radical’s non-specific reactivity also makes it less likely that it will react with a vital cellular component. Other less reactive free radicals may be more toxic in that they can mediate damage at some distance from where they are formed.


Nitric Oxide Free Radical Species Free Radical Superoxide Normal Human Blood Sperm Whale Myoglobin 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Chris E. Cooper
    • 1
  • Jaume Torres
    • 1
  • Martyn A. Sharpe
    • 1
  • Mike T. Wilson
    • 1
  • Dimitri A. Svistunenko
    • 1
  1. 1.Department of Biological and Chemical Sciences Central CampusUniversity of EssexColchesterUK

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