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Factors Influencing Tumor-Selective Localization of Antibody Conjugates

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Enzyme-Prodrug Strategies for Cancer Therapy

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Abstract

Almost a century ago the concept of targeting diseased cells using “magic bullets” was proposed by Paul Ehrlich. He envisioned that antibodies, newly described by Emil Behring, which could “in the manner of magic bullets, seek out the enemy,” might be used to create highly specific magic bullet drugs. However, it was not until 1978 that a tumor was localized with radiolabeled antibodies in a patient (Goldenberg et al., 1978). The search for suitable targets for those magic bullets, in the form of tumor-specific antigens, started in earnest in the late 1970s with the development of hybridoma technology by Köhler and Milstein (1975). This ability to produce large quantities of monoclonal antibodies (Mabs), reagents of a defined and monospecific nature, greatly facilitated the immunological mapping of the cell plasma membrane and provided a means for targeting cytotoxic drugs specifically at cancer cells.

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Authors and Affiliations

  1. Centre for Applied Microbiology & Research, Salisbury, SP4 0JG, UK

    M. A. Sims

  2. Enzacta Ltd., Salisbury, SP4 OJQ, UK

    Roger G. Melton

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  1. M. A. Sims
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  2. Roger G. Melton
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Editors and Affiliations

  1. Enzacta Ltd., Porton Down, Wiltshire, UK

    Roger G. Melton

  2. Imperial College School of Medicine, Charing Cross Campus, London, UK

    Richard J. Knox

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© 1999 Springer Science+Business Media New York

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Sims, M.A., Melton, R.G. (1999). Factors Influencing Tumor-Selective Localization of Antibody Conjugates. In: Melton, R.G., Knox, R.J. (eds) Enzyme-Prodrug Strategies for Cancer Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4823-2_3

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  • DOI: https://doi.org/10.1007/978-1-4615-4823-2_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7186-1

  • Online ISBN: 978-1-4615-4823-2

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