The Big Book of Aldehyde Dehydrogenase Sequences

An Overview of the Extended Family
  • John Perozich
  • Hugh Nicholas
  • Ronald Lindahl
  • John Hempel

Abstract

Traditionally, research on aldehyde dehydrogenases (ALDHs, EC 1.2.1) has focused on three groups: class 1, 2, and 3 ALDHs. Class 1 and 2 ALDHs are very closely related homotetramers and both participate in ethanol metabolism, though class 1 ALDHs can oxidize wide range of metabolites, including retinal (reviewed Lindahl, 1982; Yoshida et al., 1). Class 3 ALDHs appear at first glance to be highly divergent from the other 2 classes. Class 3 ALDHs share only about 25% sequence identity with class 1 and 2 ALDHs and are homodimers. However, in main-chain folding, the structures of the class 2 and 3 monomers are nearly identical (Hempel et al., 1999)

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • John Perozich
    • 1
  • Hugh Nicholas
    • 2
  • Ronald Lindahl
    • 3
  • John Hempel
    • 4
  1. 1.Department of Molecular Genetics and BiochemistryUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Pittsburgh Supercomputing CenterCarnegie-Mellon UniversityPittsburghUSA
  3. 3.Department of Biochemistry and Molecular BiologyUniversity of South DakotaVermillionUSA
  4. 4.Department of Biological SciencesUniversity of PittsburghPittsburghUSA

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