Predictive Power of the Tumor Oxygenation Status

  • P. Vaupel
  • M. Hoeckel
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 471)

Abstract

In most solid tumors the tissue pO2 status is poorer than in normal tissue at the site of tumor growth (for reviews see Vaupel et al., 1996, 1998; Vaupel and Hoeckel, 1998). Peculiarities of tumor tissue oxygenation can mainly be attributed to characteristic structural and functional abnormalities of the tumor microcirculation (perfusion-limited O2 delivery), to a deterioration of the diffusion-geometry (diffusion-limited O2 delivery), and—in some cases—to a reduced O2 carrying capacity of the blood due to tumor-associated anemia.

Keywords

Cervical Cancer Soft Tissue Sarcoma Uterine Cervix Tumor Hypoxia Tumor Oxygenation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Becker A, Haensgen G, Richter C, and Dunst J (1998) Comparison of oxygenation status of primary tumours, their neck node metastases and normal tissue in squamous cell carcinoma of the head and neck. Strahlenther Onkol, in press.Google Scholar
  2. Brizel DM, Rosner G, Harrelson J, Prosnitz LR, and Dewhirst MW (1994) Pretreatment oxygenation profiles of human soft tissue sarcomas. Int J Radiat Oncol Biol Phys 30:635–642.PubMedCrossRefGoogle Scholar
  3. Brizel DM, Rosner GL, Prosnitz LR, and Dewhirst MW (1995) Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases. Int J Radiat Oncol Biol Phys 32:1121–1125.PubMedCrossRefGoogle Scholar
  4. Brizel DM, Scully SP, Harrelson JM, Layfield LJ, Dodge RK, Charles HC, Samuslski TV, Prosnitz LR, and Dewhirst MW (1996) Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas. Cancer Res 56:5347–5350.PubMedGoogle Scholar
  5. Brizel DM, Sibley GS, Prosnitz LR, Scher RL, and Dewhirst MW (1997) Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 38:285–289.PubMedCrossRefGoogle Scholar
  6. Brizel DM, Scher RL, and Dewhirst MW (1998) Oxyganation of head and neck cancer: Impact on treatment outcome and changes during radiotherapy. 10th International Conference on Chemical Modifiers of Cancer Treatment, Clearwater, FL.Google Scholar
  7. Fyles AW, Milosevic M, Wong R, Kavanagh M-C, Pintilie M, Sun A, Chapman W, Levin W, Manchul L, Keane TJ, and Hill RP (1998a) Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol 48:149–156.PubMedCrossRefGoogle Scholar
  8. Fyles AW, Milosevic M, Wong R, Kavanagh M-C, Pintilie M, Chapman W, Levin W, Manchul L, Keane TJ, and Hill RP (1998b) Oxygenation in cervix cancer predicts radiation response and survival. 10th International Conference on Chemical Modifiers of Cancer Treatment, Clearwater, FL.Google Scholar
  9. Haensgen G, Becker A, and Dunst J (1997) Untersuchungen zum Verhaeltnis des Sauerstoffpartialdruckes unter der Strahlentherapie am Beispiel des inoperablen Uteruszervixkarzinoms. Strahlenther Onkol 173:591.Google Scholar
  10. Hoeckel M and Vaupel P (1998) The prognostic significance of hypoxia in cervical cancer: A radiobiological or tumor biological phenomenon? In: Medical Radiology—Diagnostic imaging and radiation oncology. Blood perfusion and microenvironment of human tumors (Molls M, Vaupel P, Eds) Springer, Berlin, Heidelberg, New York, pp. 73–79.Google Scholar
  11. Hoeckel M, Schlenger K, Knoop C, and Vaupel P (1991) Oxygenation of carcinomas of the uterine cervix: Evaluation of computerized O2 tension measurements. Cancer Res 51:6098–6102.Google Scholar
  12. Hoeckel M, Knoop C, Schlenger K, Vorndran B, Mitze M, Knapstein PG, and Vaupel P (1993) Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol 26:45–50.CrossRefGoogle Scholar
  13. Hoeckel M, Schlenger K, Mitze M, Schaeffer U, and Vaupel P (1996a) Hypoxia and radiation response in human tumors. Sem Radiat Oncol 6:3–9.CrossRefGoogle Scholar
  14. Hoeckel M, Schlenger K, Aral B, Mitze M, Schaeffer U, and Vaupel P (1996b) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56:4509–4515.Google Scholar
  15. Hoeckel M, Schlenger K, Hoeckel S, Aral B, Schaeffer U, and Vaupel P (1998) Tumor hypoxia in pelvic recurrences of cervical cancer. Int J Cancer 97:365–369.Google Scholar
  16. Hohenberger P and Dragon S (1995) In situ oxygen partial pressure measurements in human soft tissue sarcomas. In: Tumor Oxygenation (Vaupel PW, Kelleher DK, Guenderoth M, Eds) Gustav Fischer, Stuttgart, Jena, New York, pp. 327–333.Google Scholar
  17. Hohenberger P, Feigner C, Haensch W, and Schlag PM (1998) Tumor oxygenation correlates with molecular growth determinants in breast cancer. Breast Cancer Res Treatment 48:97–106.CrossRefGoogle Scholar
  18. Kallinowski F and Buhr HJ (1995) Tissue oxygenation of primary, metastatic and xenografted rectal cancers. In: Tumor Oxygenation (Vaupel PW, Kelleher DK, Guenderoth M, Eds) Gustav Fischer, Stuttgart, Jena, New York, pp. 205–209.Google Scholar
  19. Kallinowski F, Zander R, Hoeckel M, and Vaupel P (1990) Tumor tissue oxygenation as evaluated by computerized pO2-histography. Int J Radiat Oncol Biol Phys 19:953–962.PubMedCrossRefGoogle Scholar
  20. Lartigau E, Le Ridant AM, Lambin P, Weeger P, Martin L, Sigal R, Lusinchi A, Luboinski B, Eschwege F, and Guichard M (1993) Oxygenation of head and neck tumors. Cancer 71:2319–2325.PubMedCrossRefGoogle Scholar
  21. Lyng H, Sundfor K, Trope G, and Rofstad EK (1996) Oxygen tension and vascular density in human cervix carcinoma. Brit J Cancer 74:1559–1563.PubMedCrossRefGoogle Scholar
  22. Lyng H, Sundfor K, Tanum G, and Rofstad EK (1997) Oxygen tension in primary tumours of the uterine cervix and lymph node metastases of the head and neck. Adv Exp Med Biol 428:55–60.PubMedCrossRefGoogle Scholar
  23. Mattern J, Kallinowski F, Herfarth C, and Volm M (1996) Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer. Int J Cancer 67:20–23.PubMedCrossRefGoogle Scholar
  24. Nordsmark M, Bentzen SM, and Overgaard J (1994) Measurement of human tumour oxygenation status by a polarographic needle electrode. Acta Oncol 33:383–389.PubMedCrossRefGoogle Scholar
  25. Nordsmark M, Hoyer M, Keller J, Nielsen OS, Jensen OM, and Overgaard J (1996a) The relationship between tumor oxygenation and cell proliferation in human soft tissue sarcomas. Int J Radiat Oncol Biol Phys 35:701–708.PubMedCrossRefGoogle Scholar
  26. Nordsmark M, Overgaard M, and Overgaard J (1996b) Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 41:31–39.PubMedGoogle Scholar
  27. Nordsmark M, Keller J, Nielsen OS, Lundorf E, and Overgaard J (1997) Tumour oxygenation assessed by polarographic needle electrodes and bioenergetic status measured by 31P magnetic resonance spectroscopy in human soft tissue tumours. Acta Oncol 36:565–571.PubMedCrossRefGoogle Scholar
  28. Nordsmark M, Keller J, Nielsen OS, Jensen OM, and Overgaard J (1998) Tumor hypoxia is associated with poor prognosis in patients with soft tissue sarcomas. 10th International Conference on Chemical Modifiers of Cancer Treatment, Clearwater, FL.Google Scholar
  29. Rampling R, Cruickshank G, Lewis AD, Fitzsimmons SA, and Workman P (1994) Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumours. Int J Radiat Oncol Biol Phys 29:427–432.PubMedCrossRefGoogle Scholar
  30. Runkel S, Wischnik A, Teubner J, Kaven E, Gaa J, and Melchert F (1994) Oxygenation of mammary tumors as evaluated by ultrasound-guided computerized-pO2-histography. Adv Exp Med Biol 345:451–458.PubMedCrossRefGoogle Scholar
  31. Schorcht J, Neumann H, Eberhardt HJ, and Neumann U (1997) Untersuchungen zur Oxygenierung inoperabler gynaekologischer Tumoren. Strahlenther Onkol 173:589.Google Scholar
  32. Schwickert G, Walenta S, Sundfor K, Rofstad EK, and Mueller-Klieser W (1995) Correlation of high lactate levels in human cervical cancer with incidence of metastasis. Cancer Res 55:4757–4759.PubMedGoogle Scholar
  33. Strnad V, Keilholz L, Kirschner M, Meyer M, and Sauer R (1997) Sauerstoffdruckverteilung in Lymphknotenmetastasen und die Veraenderungen waehrend akuter respiratorischer Hypoxie. Strahlenther Onkol 173:267–271.PubMedCrossRefGoogle Scholar
  34. Sundfor K, Lyng H, Kongsgard U, Tropé C, and Rofstad EK (1997) Polarographic measurement of pO2 in cervix carcinoma. Gynecol Oncol 64:230–236.PubMedCrossRefGoogle Scholar
  35. Terris DJ and Dunphy EP (1994) Oxygen tension measurements of head and neck cancers. Arch Otolaryngol Head Neck Surg 120:283–287.PubMedCrossRefGoogle Scholar
  36. Vaupel P (1996) Oxygen transport in tumors: Characteristics and clinical implications. Adv Exp Med Biol 388:341–351.PubMedCrossRefGoogle Scholar
  37. Vaupel P (1997) Blood flow and O2-status of head and neck carcinomas. Adv Exp Med Biol 428:89–95.PubMedCrossRefGoogle Scholar
  38. Vaupel P and Hoeckel M (1998) Oxygenation of human tumors. In: Medical Radiology—Diagnostic Imaging and Radiation Oncology. Blood Perfusion and Microenvironment of Human Tumors—Implications for Clinical Radiooncology (Molls M, Vaupel P, Eds) Springer, Berlin, Heidelberg, New York, pp. 63–72.Google Scholar
  39. Vaupel P, Schlenger K, Knoop C, and Hoeckel M (1991) Oxygenation of human tumors: Evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res 51:3316–3322.PubMedGoogle Scholar
  40. Vaupel P, Thews O, and Hoeckel M (1996) Tumor oxygenation: Characterization and clinical implications. In: Erythropoietin in Cancer Supportive Treatment (Smyth JF, Boogaerts MA, Ehmer BR-M, Eds) Marcel Dekker, New York, Basel, pp. 205–239.Google Scholar
  41. Vaupel P, Thews O, Kelleher DK, and Hoeckel M (1998) Current status of knowledge and critical issues in tumor oxygenation: Results from 25 years research in tumor pathophysiology. Adv Exp Med Biol, in press.Google Scholar
  42. Walenta S, Salameh A, Lyng H, Evensen JF, Mitze M, Rofstad EK, and Mueller-Klieser W (1997) Correlation of high lactate levels in head and neck tumors with incidence of metastasis. Amer J Pathol 150:409–415.Google Scholar
  43. Wong RKW, Fyles A, Milosevic M, Pintilie M, and Hill RP (1997) Heterogeneity of polarographic oxygen tension measurements in cervix cancer: an evaluation of within and between tumor variability, probe position, and track depth. Int J Radiat Oncol Biol Phys 39:405–412.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • P. Vaupel
    • 1
  • M. Hoeckel
    • 2
  1. 1.Institute of Physiology and PathophysiologyUniversity of MainzMainzGermany
  2. 2.Department of Obstetrics and GynecologyUniversity of LeipzigLeipzigGermany

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