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Triptans

A Support to the Central Link between Serotonin and Acetylcholine in Migraine
  • Maria Nicolodi
  • Federigo Sicuteri
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 467)

Abstract

Recently synthesized triptans, sumatriptan derivatives, display aborting migraine activity at doses and with plasmatic maximum peak dramatically lower (20-40 times) than sumatriptan, the 5-HT like agonist, which is the original molecule. That triptans easily cross blood-brain barrier strongly supports the central theory of migraine. We recently discovered the anti-migraine prophylactic action of centrally acting anti-cholinesterase agents, that seems a further support to the central theory of migraine. Indeed, acetylcholine is an important analgesia neurotransmitter and is intertwined with 5-HT central pathways.

Keywords

Cluster Headache Migraine Attack Chronic Migraine Central Theory Migraine Sufferer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Maria Nicolodi
    • 1
  • Federigo Sicuteri
    • 1
  1. 1.Department of Internal Medicine and TherapeuticsInteruniversity Centre of Neurochemistry and Clinical Pharmacology of Idiopathic HeadacheFlorenceItaly

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