Inflammation and Fibrosis

  • David J. P. Bassett
  • Deepak K. Bhalla


Inflammatory cells represent an important component of the pulmonary defenses, but they also play a critical role in the pathogenesis of lung disorders such as adult respiratory distress syndrome (Patterson et al., 1989), asthma (Bigby and Nadel, 1988), silicosis (Lugano et al., 1984; Sjostrand et al., 1991; Li et al., 1992), interstitial pulmonary fibrosis, and asbestosis (Sibille and Reynolds, 1990; Rochester and Elias, 1993; Gee and Mossman, 1995). Because of the generally recognized adverse effects of airway inflammation and contribution of inflammatory cells to lung fibrosis, the factors involved in inflammatory reactions, mechanisms of toxicity and development of chronic lung disease have received considerable attention. The initial steps in the cascade of events, that ultimately result in the development of chronic lung disease, include stimulation of resident cells, release of chemotactic agents and recruitment of inflammatory cells. These events can be set in motion by an intrapulmonary insult in the form of an acute or chronic inhalation exposure to either environmental or occupational pollutants.


Lung Injury Acute Lung Injury Alveolar Macrophage Idiopathic Pulmonary Fibrosis Pulmonary Fibrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • David J. P. Bassett
    • 1
  • Deepak K. Bhalla
    • 1
  1. 1.Department of Occupational and Enviornmental Health SciencesWayne State UniversityDetroitSUA

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