The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer

  • Douglas Yee
  • Neal Rosen
  • Roberto E. Favoni
  • Kevin J. Cullen
Part of the Cancer Treatment and Research book series (CTAR, volume 53)


The ability to grow breast cancer cells in vitro has lead to the identification of several polypeptide hormones that may regulate their growth. The insulin- like growth factors (IGFs) have been identified as potent mitogens for breast cancer cells in vitro and increasing evidence has suggested that the IGFs may have an important function in the proliferation of mammary epithelia. This chapter will examine the data that support a role for the IGFs in regulating the growth of breast cancer cells.


Breast Cancer Cell Breast Cancer Cell Line Malignant Epithelial Cell Human Mammary Carcinoma Cell Line Western Ligand Blotting 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Douglas Yee
  • Neal Rosen
  • Roberto E. Favoni
  • Kevin J. Cullen

There are no affiliations available

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