The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer
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The ability to grow breast cancer cells in vitro has lead to the identification of several polypeptide hormones that may regulate their growth. The insulin- like growth factors (IGFs) have been identified as potent mitogens for breast cancer cells in vitro and increasing evidence has suggested that the IGFs may have an important function in the proliferation of mammary epithelia. This chapter will examine the data that support a role for the IGFs in regulating the growth of breast cancer cells.
KeywordsBreast Cancer Cell Breast Cancer Cell Line Malignant Epithelial Cell Human Mammary Carcinoma Cell Line Western Ligand Blotting
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