Signaling Events in T-Lymphocyte-Dependent B-Lymphocyte Activation

  • John C. Cambier
  • Kathrin L. Lehmann
  • William F. Wade
Chapter
Part of the Blood Cell Biochemistry book series (BLBI, volume 3)

Abstract

The B-cell immune response is initiated in vivo by antigen binding to antigen-specific membrane immunoglobulin (mIg) molecules. Binding leads to antigen uptake, processing by proteases, and reexpression, now as immunogenic peptides in association with major histocompatibility complex, (MHC)-encoded class II (Ia) molecules (for a review, see Chesnut and Grey, 1986; Rock et al., 1984). Antigen binding to mIg also leads to signal transduction stimulating alterations in various cellular processes of the B cell (for a review, see Cambier and Ransom, 1987; DeFranco, 1987). Depending on its structure, binding of antigen to B-cell mlg may at one extreme provide a stimulus sufficient to induce expression of a large complex of genes that cause B-cell proliferation and differentiation into antibody-secreting plasma cells or, alternatively, it may stimulate expression of only a limited set of genes (Cambier and Ransom, 1987; DeFranco, 1987; Finkelman et al., 1986).

Keywords

Major Histocompatibility Complex Phorbol Myristate Acetate Phorbol Myristate Acetate cAMP Generation Cell Conjugate Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • John C. Cambier
    • 1
  • Kathrin L. Lehmann
    • 1
  • William F. Wade
    • 1
  1. 1.Department of Pediatrics, Divisions of Basic Sciences and Basic ImmunologyNational Jewish Center for Immunology and Respiratory MedicineDenverUSA

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