Regulation of Gene Expression by Epidermal Growth Factor

  • Laurie G. Hudson
  • Gordon N. Gill
Chapter
Part of the Genetic Engineering book series (GEPM, volume 13)

Abstract

Many constituents of serum and of the extracellular environment are essential for stimulation of cell growth and maintenance of differentiated function. Peptide growth factors form one subset of such components and epidermal growth factor (EGF) is one of the best-defined members of this class of growth regulatory substances. Many advances have been made in understanding mechanisms which underlie biological activities of EGF since it was first described by Stanley Cohen as a peptide present in nerve growth factor preparations that promoted early eyelid opening and tooth eruption in mice (1). Because physiological and cellular responses to EGF have been widely reviewed (2–6), this article emphasizes the role of EGF in regulating gene expression.

Keywords

Epidermal Growth Factor Receptor Mutant Epidermal Growth Factor Receptor Epidermal Growth Factor Receptor Gene Serum Response Factor GTPase Activate Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Laurie G. Hudson
    • 1
    • 2
  • Gordon N. Gill
    • 1
    • 2
  1. 1.Department of Medicine, Division of Endocrinology and MetabolismUniversity of CaliforniaSan Diego, La JollaUSA
  2. 2.Center for Molecular GeneticsUniversity of California, San DiegoLa JollaUSA

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