Cell Signaling in LPS Primed and PAF Stimulated P388D1 Macrophage-Like Cells

  • R. Asmis
  • E. A. Dennis
Chapter
Part of the Developments in Oncology book series (DION, volume 71)

Abstract

Macrophages play an important role in the pathogenesis of inflammation and other diseases. An early event in the activation of macrophages is the release of arachidonic acid (AA) and the subsequent formation of eicosanoids such as prostaglandins (PG), leukotrienes (LT), and thromboxanes (TX) (1). The metabolism of eicosanoids and their role in the inflammatory response have been described (2). The rate-limiting event in the biosynthesis of these inflammatory mediators is believed to be controlled by a phospholipase type enzyme, the simplest mechanism being the release of AA from the sn-2 position of phospholipids by a phospholipase A2 (PLA2) (3).

Keywords

Arachidonic Acid Arachidonic Acid Release Calcium Ionophore A23187 P388D1 Cell Resident Peritoneal Macrophage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • R. Asmis
    • 1
  • E. A. Dennis
    • 1
  1. 1.Department of Chemistry and Center for Molecular GeneticsUniversity of California at San DiegoLa JollaUSA

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