The New Anticancer Drug Ilmofosine Enhances the Activity of CIS-Platin and Reverses Multidrug Resistance

  • J. Hofmann
  • A. Wolf
  • M. Spitaler
  • F. Uberall
  • D. B. J. Herrmann
  • H. Grunicke
Chapter
Part of the Developments in Oncology book series (DION, volume 71)

Abstract

It is well established that the alkyllysophospholipid ilmofosine (BM 41 440) exhibits antiproliferative activity on tumor cells, but not on bone marrow. Here we demonstrate synergism in antitumor activities of a combination of ilmofosine with cis-platin. We also show that 0.1 μM ilmofosine reverses the multidrug resistance of KB-8-5 cells to the sensitivity of KB-3-1 cells.

Keywords

Anticancer Drug Multidrug Resistance Combination Index Vinca Alkaloid Cervix Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • J. Hofmann
    • 1
  • A. Wolf
    • 1
  • M. Spitaler
    • 1
  • F. Uberall
    • 1
  • D. B. J. Herrmann
    • 2
  • H. Grunicke
    • 1
  1. 1.Institute of Medicinal Chemistry and BiochemistryUniversity of InnsbruckInnsbruckAustria
  2. 2.Department of ImmunopharmacologyBoehringer MannheimMannheim 31Germany

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