Smokeless Tobacco and Aerodigestive Tract Cancers: Recent Research Directions

  • Deborah M. Winn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 320)

Abstract

Though smokeless tobacco, which includes chewing tobacco and snuff, was the most common form of tobacco used at the turn of the century (1), its use declined over subsequent decades. In the mid-1970s, however, its popularity again rose, leading to a 56% increase in snuff use from 1970 to 1985, accounted for by moist snuff, and a 36% increase in chewing tobacco, attributed to loose-leaf tobacco (2). With the exception of a leveling off around 1987, this upward trend in use has continued (3).

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References

  1. 1.
    Schuman LM. Patterns of smoking behavior. NIDA Monograph 17:36–66, 1977.Google Scholar
  2. 2.
    Advisory Committee to the Surgeon General. The Health Consequences of Using Smokeless Tobacco (NIH Publication No. 86–2874). Bethesda, MD: U.S. Department of Health and Human Services, 1986, p. 7.Google Scholar
  3. 3.
    U.S. Department of Agriculture. Tobacco Situation. No. TS215. June 1991.Google Scholar
  4. 4.
    Winn DM, Blot WJ, Shy CM, Pick le LW, Toledo A, Fraumeni JF Jr. Snuff dipping and oral cancer among women in the southern United Suites. N Engl J Med 304:745–749, 1981.PubMedCrossRefGoogle Scholar
  5. 5.
    Mason TJ, McKay FW, Hoover R, Blot WJ, Fraumeni JF Jr. Atlas of cancer mortality for U.S. counties, 195069 (NIH Publication No. 75–780). Bethesda, MD: U.S. Department of Health and Human Services, 1975, p. 37.Google Scholar
  6. 6.
    International Agency for Research on Cancer. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Tobacco Habits Other Than Smoking; Betel-quid and Areca-nut Chewing; and Some Related Nitrosamines. Vol. 37. Lyon, France: International Agency for Research on Cancer, 1985, pp. 37–136.Google Scholar
  7. 7.
    Hoffmann D, Hecht SS. Nicotine-derived N-nitrosamines and tobacco-related cancer: Current status and future directions. Cancer Res 45:935.-944, 1985.PubMedGoogle Scholar
  8. 8.
    Hoffmann D, Adams JD, Lisk D, Fisenne I, Brunnemann KD. Toxic and carcinogenic agents in dry and moist snuff. J Nail Cancer Inst 79:1281–1286, 1987.Google Scholar
  9. 9.
    National Institutes of Health Consensus Development Conference Statement. Health Implications of Smokeless Tobacco. Vol. 6, No. 1. Bethesda, MD: National Institutes of Health, 1986.Google Scholar
  10. 10.
    Comprehensive Smokeless Tobacco Health Education Act of 1986. Public Law 99–252. February 27, 1986.Google Scholar
  11. 11.
    Spitz MR, Fueger JJ, Goepfert H, Hong WK, Newell GR. Squamous cell carcinoma of the upper aerodigestive tract: A case comparison analysis. Cancer 61:203–208, 1988.PubMedCrossRefGoogle Scholar
  12. 12.
    Stockwell HG, Lyman G H. Impact of smoking and smokeless tobacco on the risk of cancer of the head and neck. Head Neck Surg 9:104–1 10, 1986.Google Scholar
  13. 13.
    Blot WJ, McLaughlin JK, Winn DM, Austin DF, Greenberg RS, Preston-Martin S, Bernstein L, Schoenberg JB, Stemhagen A, Fraumeni JF Jr. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res 48:3282–3287, 1988.PubMedGoogle Scholar
  14. 14.
    Schoenborn CA, Boyd G. Smoking and other tobacco use: United States, 1987. National Center for Health Statistics. Vital Health Stat 10(169), 1989.Google Scholar
  15. 15.
    U.S. Department of Health and Human Services. Reducing the Health Consequences of Smoking: 25 Years of Progress. A Report of the Surgeon General (DHHS Publication No. (CDC) 89–8411). Rockville, MD: U.S. Department of Health and Human Services, 1989, p. 320.Google Scholar
  16. 16.
    Schantz SP, Byers RM, Goepfert H. Tobacco and cancer of the tongue in young adults (letter). JAMA 259:1943–1944, 1988.PubMedCrossRefGoogle Scholar
  17. 17.
    Shemen LJ, Klotz J, Schottenfeld D, Strong EW. Increase of tongue cancer in young men (letter). JAMA 252:1857, 1984.PubMedCrossRefGoogle Scholar
  18. 18.
    Depue RH. Rising mortality from cancer of the tongue in young white males (letter). N Engl J Med 315:647,1986.PubMedGoogle Scholar
  19. 19.
    Davis S, Severson RK. Increasing incidence of cancer of the tongue in the United States among young adults (letter). Lancet 2:910–911, 1987.PubMedCrossRefGoogle Scholar
  20. 20.
    Emster VL, Grady DG, Greene JC, Walsh M, Robertson P, Daniels TE, Benowitz N, Siegel D, Gerbert B, Hauck WW. Smokeless tobacco use and health effects among baseball players. JAMA 264:218–224, 1990.CrossRefGoogle Scholar
  21. 21.
    Prevalence of oral lesions and smokeless tobacco use in Northern Plains Indians. MMWR 37:608–611, 1988.Google Scholar
  22. 22.
    Desai PB. Problems and challenges clue to tobacco-related cancer: A clinical perspective. Presented at the International Symposium on the Control of Tobacco-Related Cancers and Other Diseases. Bombay, India: January 15–19, 1990.Google Scholar
  23. 23.
    Sankaranarayanan R, Duffy SW, Padmakumary G, Day NE, Nari MK. Risk factors for cancer of the buccal and labial mucosa in Kerala, Southern India. J Epidemiol Community Health 44:286–292, 1990.PubMedCrossRefGoogle Scholar
  24. 24.
    Jayant K, Balakrishnan V, Sanghvi LD, Jussawalla DJ. Quantification of the role of smoking and chewing tobacco in oral, pharyngeal and oesophageal cancers. Br J Cancer 35:232–235, 1977.PubMedCrossRefGoogle Scholar
  25. 25.
    Notani PN. Role of alcohol in cancer of the upper alimentary tract: Use of models in risk assessment. J Epidemiol Community Health 42:187–192, 1988.PubMedCrossRefGoogle Scholar
  26. 26.
    Hirsch JM, Hohansson SL. Effect of long-term application of snuff on oral mucosa: An experimental study in the rat. J Oral Pathol 12:187–198, 1983.PubMedCrossRefGoogle Scholar
  27. 27.
    Hecht SS, Rivenson A, Braley J, DiBelloJ, Adams JD, Hoffmann D. Induction of oral cavity tumors in F344 rats by tobacco-specific nitrosamines and snuff. Cancer Res 46:4162–4166, 1986.PubMedGoogle Scholar
  28. 28.
    Park N-H, Sapp JP, Herbosa EG. Oral cancer induced in hamsters with herpes simplex infection and simulated snuff dipping. Oral Surg Oral Med Oral Pathol 62:164–168, 1986.PubMedCrossRefGoogle Scholar
  29. 29.
    Oh JS, Cherrick HM, Park N-H. Effect of snuff extract on the replication and synthesis of viral DNA and proteins in cells infected with herpes simplex virus. J Oral Maxillofac Surg 48:373–379, 1990.PubMedCrossRefGoogle Scholar
  30. 30.
    Correa E, Joshi PV, Castonguay A, Schuller HM. The tobacco-speci fie n itrosamine 4-(methylnitrosamino)-1 -(3- pyridy1)-1-butanone is an active transplacental carcinogen in Syrian golden hamsters. Cancer Res 50:3435–3438, 1990.PubMedGoogle Scholar
  31. 31.
    Hecht SS, Hoffmann D. Tobacco-specific nitrosamines: An important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis 9:875–884, 1988.PubMedCrossRefGoogle Scholar
  32. 32.
    Lindemann RA, Park NH. Inhibition of human lymphokine-activated k iller activity by smokeless tobacco (snuff) extract. Arch Oral Biol 33:317–321,1988.PubMedCrossRefGoogle Scholar
  33. 33.
    Anderson RA, Burton HR, Fleming PD, Hamilton-Kemp TR. Effect of storage conditions on nitrosated, acylated, and oxidized pyridine alkaloid derivatives in smokeless tobacco products. Cancer Res 49:5895–5900, 1989.Google Scholar
  34. 34.
    Tricker AR, Haubner R, Spiegelhalder B, Preussmann R. The occurrence of tobacco-specific nitrosamines in oral tobacco products and their potential formation under simulated gastric conditions. Food Chem Toxicol 26:861–865,1988.PubMedCrossRefGoogle Scholar
  35. 35.
    Hecht SS, Trushin N, Castonguay A, Rivenson A. Comparative carcinogenicity and DNA methylation in F344 rus by 4-(methylnitrosamino)-1-(3-pyridyl)-l-buttnone and N-nitrosodimethylamine. Cancer Res 46:498–502, 1986.PubMedGoogle Scholar
  36. 36.
    Castonguay A, Tharp R, Hecht SS. Kinetics of DNA methylation by the tobacco-specific carcinogen 4(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the F344 rat. In O’Neill IK, von Borstel RC, Miller CT, Long JT, Bartsch H (eds): N-Nitroso Compounds: Occurrence, Biological Effects and Relevance to Human Cancer. IARC Scientific Publications No. 57. Lyon, France: International Agency for Research on Cancer, 1984, pp. 787–796.Google Scholar
  37. 37.
    Hulka BS. Overview of biological markers. In Hulka BS, Wilcosky TC, Griffith JD (eds): Biological Markers in Epidemiology. New York: Oxford University Press, 1990, pp. 3–4.Google Scholar
  38. 38.
    Murphy SE, Palomino A, Hecht SS, Hoffmann D. A dose response study of DNA adduct formation and hemoglobin adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats. Cancer Res 50:5446–5452, 1990.PubMedGoogle Scholar
  39. 39.
    Cannella SG, Kagan SS, Kagan M, Foiles PG, Palladino G, Quart AM, Quart E, Hecht SS. Mass spectrometric analysis of tobacco-specific nitrossun ine hemoglobin adducts in snuff dippers, smokers, and nonsmokers. Cancer Res 50:5438–5445, 1990.Google Scholar
  40. 40.
    Chack M, Gupta RC. Evaluation of DNA damage in the oral mucosa of tobacco users and non-users by 32P-adduct assay. Carcinogenesis 9:2309–2313, 1988.CrossRefGoogle Scholar
  41. 41.
    Stich HF, Dunn BP. DNA adducts, micronuclei, and leukoplakias as intermediate endpoints in intervention trials. In Bartsch H, Hemminki K, O’Neill IK. Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention. IARC Scientific Publications No. 89. Lyon, France: International Agency for Research on Cancer, 1988, pp. 137–145.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Deborah M. Winn
    • 1
  1. 1.National Center for Health StatisticsCenters for Disease ControlHyattsvilleUSA

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