Recovery from Brain Damage pp 67-78 | Cite as
Neural Implants and Recovery of Function: Human Work
Abstract
Organ transplantation is an accepted treatment for renal, hepatic and cardiorespiratory diseases and the principles of harvesting and transplantation technique, together with the maintenance of organ function are well established. The ethical aspects of harvesting have been widely debated52,61 and, in most countries, appropriate regulations have been formulated which support and, indeed, may encourage organ donation. As regards neural transplantation, however, these principles are yet to be agreed and the clinical value established. Consequently, the management of patients with neural degenerative disease, who potentially have much to gain, is uncertain and, the ethical issues are still hotly debated.23,43,47,52,55,61
Keywords
Caudate Nucleus Ventral Mesencephalon Neural Transplantation Stereotactic Technique Open CraniotomyPreview
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References
- 1.Allen, G.S., Burns, R.C., Tulipan, N.B., and Parker, R.A, 1988, Adrenal medullary transplantation to the caudate nucleus in Parkinson’s Disease, Arch. Neurol., 46, 487–491.Google Scholar
- 2.Anden, N.E., Dahlstrom, A., Fuxe, K., and Larsson, K., 1966, Functional role of the nigroneostriatal dopamine neurones, Acta. Pharmacol. Toxicol., 24, 263–274.Google Scholar
- 3.Backlund, E.O., Granberg, P.O., Hamberger, B., Gedvall, G. Seigar, A., and Olsen, L., 1985, Transplantation of adrenal mdedullary tissue to striatum in Parkinsonism. First clinical trials, J. Neurosurg., 62, 169–173.Google Scholar
- 4.Bankiewicz, K.S., Jacobowitz, D.M., Plunkett, R.J. Oldfield, E.H., and Kopen, I.J., 1987, Injury induced sprouting into the caudate nucleus, after solid tissue implantation in MPTP-induced Parkinsonism monkeys, Soc. of Neurosc. Abs., 46, 16.Google Scholar
- 5.Bankiewicz, K.S., Plunkett, R.J., Mefford, I. Kopin, I.J., and Oldfield, E.G., 1990, Behavioural recovery from MPTP-induced Parkinsonism in monkeys after intracerebral tissue implants is not related to CSF concentrations of dopamine metabolites, Prog. in Brain Research, 82, 561–671, Elsevier, Amsterdam.Google Scholar
- 6.Barker, R.A, Cahn, A.P., 1988, Parkinson’s Disease: an autoimmune process, Int. J Neurol., 43, 1–7.Google Scholar
- 7.Björklund, A., Dunnett, S.B., Stenevi, U., Lewis, M.E., and Iverson, S.D., 1980, Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing, Brain Res., 199, 307–333.Google Scholar
- 8.Björklund, A., Kromer, L.F., and Stenevi, U., 1979, Cholinergic reinnervation of the rat hippocampus by septal implants is stimulated by perforant path lesion, Brain Res., 173, 57–64.Google Scholar
- 9.Björklund, A., and Stenevi, U., 1979, Regeneration of monoaminergic and cholinergic neurones in the mammalian central nervous system, Physiol. Rev., 59, 62–100.Google Scholar
- 10.Björklund, A., Stenevi, U., Dunnett, S.B., and Gage, F.H., 1982, Cross species neural grafting in a rat model of Parkinson’s Disease, Nature, 298, 652–654.Google Scholar
- 11.Brundin, P. Nilsson, O.G., Strecker, R.E., Lindvall, O. Astedt, B., and Björklund, A., 1986, Behavioural effects of human foetal dopamine neurons grafted in a rat model of Parkinson’s Disease, Exp. Brain Res., 65, 235–240.Google Scholar
- 12.Canter, C.J., De La Torrer, D., Mier, M., 1961, A method for evaluating disability in patients with Parkinson’s Disease, J. Nero. Ment. Dis., 122, 143–147.Google Scholar
- 13.Collier, T.J., Gash, D.M., and Sladek, J.R, 1988, Transplantation of norepinephrine neurons into aged rats improves performance of a learned task, Brain Res., 448, 77–87.Google Scholar
- 14.Das, G.D. 1974, Transplantation of embryonic neural tissue in the mammalian brain. Growth and differentiation of neuroblasts from various regions of the embryonic brain in the cerebellum of neonate rats, J. of Life Sci., 93–124.Google Scholar
- 15.Das, G.D., and Hallas, H.B., 1978, Transplantation of brain tissue in the brain of adult rat, Experimentia, 34, 1304–1306.Google Scholar
- 16.Deckel, A.W., Robinson, R.G., Coyle, I.T., and Sanberg, P.R., 1983, Reversal of long term locomotor abnormalities in the Kainic Acid model of Huntington’s Disease by day 18 foetal striatal implants, European J. Pharmacol., 93, 287–288.Google Scholar
- 17.Del Conte, G., 1907, Empflanzungen von embryonalem Gewebe ins Gehurn, Beatr Path Anat. Allg. Pathol., 42, 193–203.Google Scholar
- 18.Detta, A., Grabham, P., and Hitchcock, E.R., 1992, Phenotypic plasticity of mature human foetal mesencephalic dopaminergic neurones, Restorative NeuroL and NeuroSci., (in press).Google Scholar
- 19.Detta, A., Hitchcock, E.R, 1990, The selective viability of human foetal brain cells, Brain Res., 520, 277–283.Google Scholar
- 20.Dunn, E.H., 1917, Primary and secondary findings in a series of attempts to transplant cerebral cortex in albino rat, J. Comp. Neurol., 271, 565–582.Google Scholar
- 21.Dunnett, S., Björklund, A., and Stenevi, U., 1983, Transplant-induced recovery from brain lesions. A review of the nigro-striatal model, in Neural Tissue Transplantation Research, R.B. Wallace, and G.D. Das, eds., pp. 191–216, Springer-Verlag, New York.Google Scholar
- 22.Fine, A, Hunt, S.P., Oertal, W.H., Nomoto, M., Chong, P.N., Bond, A. Waters, E., Temlett, J.A., Annett, L., Dunnett, S.R., Jenner, P., and Marsden, E.D., 1987, Transplantation of embryonic marmoset dopaminergic neurons to the corpus striatum of marmosets rendered Parkinsonian by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Prog. in Brain Res., 78, 479–489, Elsevier, Amsterdam.Google Scholar
- 23.Foetuses and Foetal Material, March 1988, Hansard, p. 243.Google Scholar
- 24.Freed, E.R, Breeze, R.E., Rosenberg, N.L., Barrett, I.N., and Rottenberg, D.A, 1989, Therapeutic effects of human foetal dopamine cells transplanted in a patient with Parkinson’s Disease, in Neural transplantation: from molecular bases to clinical application, Restorative NeuroL and Neurosci. Suppl., p. 231.Google Scholar
- 25.Freed, W.J., Morihisa, J.M. Spoor, E., Hoffer, B.J. Olson, L., Seiger, A., and Wyatt, R.J., 1981, Transplanted adrenal chromaffin cells in rat brain reduces lesion induced rotational behaviour, Nature, 292, 351–352.Google Scholar
- 26.Henderson, R.T.H., Clough, C.G., Hughes, R.C., Hitchcock, E.R., and Kenny, R.G., 1991, Implantation of human foetal ventral mesencephalon to the right caudate nucleus in advanced Parkinson’s Disease, Arch. Neurol., 48, 822–827.Google Scholar
- 27.Hitchcock, E.R, 1989, Recent experiences with dopamine transplantation for Parkinson’s Disease, in Proceedings of Society of British Neurological Surgeons, Oxford, J. Neurosurg. Psychiat., 52, 141.Google Scholar
- 28.Hitchcock, E.R., Kenny B.G., Clough E.G., Hughes, R.E., Henderson, R.T.H., and Detta, A., 1990, Stereotactic implantation of foetal mesencephalon (STIM): the UK. experience, Prog. in Brain Res., 82, 723–728, Elsevier, Amsterdam.Google Scholar
- 29.Isacson, O., Dunnett, S.R., and Björklund, A., 1986, Graft-induced behavioural recovery in an animal model of Huntington’s Disease, Proc. Nat. Acad. Sci., U.S.A, 83, 27–32.Google Scholar
- 30.Jiang, N., Jiang, E., Tang, Z., Zhung, F., and Jiang Li, S.D., 1987, Human foetal brain transplant trials in the treatment of Parkinsonism, Acta Academial Medicinae Shanghai, 14, No. 1.Google Scholar
- 31.Justice, A., Deckel, W., and Robinson, R.G., 1986, Foetal neocortical tissue survives transplantation into an ischaemic cortical site, Neurosci. Abs., 12, 1471.Google Scholar
- 32.Lampson, L.A., 1987, Molecular bases of the immune response to neural antigens, Trends in NeuroSci., 10, 211–216.Google Scholar
- 33.Le Gros Clarke, W.E., 1940, Neuronal differentiation in implanted foetal cortical tissue, Journal of NeuroL Psychiat., 3, 262–272.Google Scholar
- 34.Levivier, M., Sladek, Jr., J.R., Collier, T., Hagenmeyer-Houser, S.H., and Gash, D.M., 1989, The protective effect of various striatal implants on intrastriatal quinolinic application, Restorative Neurol. Neurosci., Suppl. 1.Google Scholar
- 35.Lindvall, O., Rehncrona, S., Brundin, P., Gustavi, B., Astedt, B. Widner, H., Lindholm, T., Björklund, A., Leenders, K, Rothwell, J.E., Frackowiak, R, Marsden, E.D., Johnels, B., Steg, G., Freedman, R., Hoffer, B.J., Seiger, A, Bygdeman, M., Stromberg, I., and Olson, L., 1989, Human foetal dopamine neurones grafted into the striatum in two patients with severe Parkinson’s Disease, Arch. Neurol., 46, 615–631.Google Scholar
- 36.Lindvall, O., Rehncrona, S., Gustavi, B., Brundin, P., Astedt, B., Widner, H., Linkholm, T., Björklund, A., Leenders, K.L., Rothwell, J.E., Frackowiak, R., Marsden, C.D., Johnels, B., Steg, G., Freedman, R., Hoffer, B.J., Seiger, A., Stromberg, I., Bygdeman, M., and Olson, L., 1988, Foetal dopamine-rich mesencephalic grafts in Parkinson’s Disease, Lancet, 1, 1483–1483.Google Scholar
- 37.Lund, R.D.Z., and Hauschka, S.D., 1976, Transplanted neural tissue develops connections with host rat brain, Science, 193, 582–584.Google Scholar
- 38.Madrazo, I., Drucker-Colin, R., Diaz, V., Martinez-Mata, J., Torres, E., and Becurri, J.J., 1987, Open microsurgical autograft of adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson’s Disease, New Eng. J Med., 316, 831–834.Google Scholar
- 39.Madrazo, I., Leon, V., Torres, E., Aguilera, M.J.E., Valera, G., Alvarez, F., Fraga, A., Colin-Drucker., R, Ostrosky, F., Skurorich, M., and Franco, R. 1988, Transplantation of foetal substantia nigra and adrenal medulla to the caudate nucleus in two patients with Parkinson’s Disease, New Eng. J Med., 318, 51.Google Scholar
- 40.Medawer, P.B., 1948, Immunity to homologous grafted skin: III The fate of skin homografts transplanted to the brain to subcutaneous tissue, and to the anterior chamber of the eye, Brit. J Exp. Path., 29, 58–59.Google Scholar
- 41.Molina, H., 1989, Neurotransplantation in Parkinson’s Disease: The Cuban Experience, in Neuro transplantation: from molecular bases to clinical application, Restor. Neurol. and NeuroSci., Suppl. 1, 230.Google Scholar
- 42.Mundrick, L.A, Leung, P.P.H., Baimbrldge, K.G., and Miller, J.J., 1988, Neuronal transplants used in the repair of acute ischaemic injury in the central nervous system, Prog. in Brain Res., 78, 87–95, Elsevier, Amsterdam.Google Scholar
- 43.Parkinson’s Disease Society Newsletter, 1988,Issue No. 65.Google Scholar
- 44.Penn, R.D., Goetz, C.G. Tanner, E.M. Klawans, H.L., Shannon, K.M., Comella, C.L., and Witt, T.R., 1988, The adrenal medullary transplant operation for Parkinson’s Disease: clinical observations if five patients, Neurosurg., 22, 999–1004.Google Scholar
- 45.Perlow, M.J., Freed, W.J., Hoffer, B.J., Seiger, A., Olson, L., and Wyatt, RJ., 1979, Brain grafts reduce motor abnormalities produced by destruction of nigro-striatal dopamine systems, Science, 204, 643–646.Google Scholar
- 46.Pycock, C.J., 1980, Turning behaviour in animals, Neuroscience, 5, 461–514.Google Scholar
- 47.Report of Board of Social Responsibility, 1990, Human Transplants, Church of Scotland and Social Work.Google Scholar
- 48.Review of the guidance on the research use of foetuses and foetal material, 1989, Report of the Polkinghome Commission, HMSO CM, 762.Google Scholar
- 49.Sladek, J.R., Collier, J.J., Haber, S.N., Roth, R.H., and Redmond, E., 1986, Survival and growth of foetal catecholamines neurones transplanted into primate brain, Brain Res. Bull., 17, 809–818.Google Scholar
- 50.Sladek, J.R., and Gash, D.M., 1988, Nerve cell-grafting in Parkinson’s Disease, J. of Neurosurg., 68, 337–351.Google Scholar
- 51.Sladek, J.R, Redmond, D.E., Collier, T.J., Haaber, S.N., Elsworth, J.D., Deutsche, A.Y., and Roth, R.H., 1987, Transplantation of foetal dopamine neurons in primate brain reserves MPTP-induced Parkinsonism, Prog. in Brain Res., 71, 309–323, Elsevier, Amsterdam.Google Scholar
- 52.Sladek, J.R., and Shoulson, I., 1988, Neural transplantation: a call for patience rather than patients, Science, 240, 1386–1388.Google Scholar
- 53.Sotelo, C., and Alvarado-Mallart, R.M., 1988, Integration of grafted Purkinje cell into the host cerebellar circuitry in Purkinje cell degeneration mutant mouse. Prog. in Brain Res., 78, 141–154, Elsevier, Amsterdam.Google Scholar
- 54.Sotelo, S., and Alvarado-Mallart, R.M., 1987, Cerebellar transplantation in adult mice with here do-degenerative ataxia. Incell and tissue transplantation into the adult brain, eds., E.C. Azmita, and A. Björklund, Annals. N. Y. Acad. of Sci., 495, 242–167.Google Scholar
- 55.Statement of the Administrative Council of the World, 1989, Federation of Neurosurgical Societies.Google Scholar
- 56.Stromberg, I., Almquist, P., Bygdeman, M., Finger, T.E., Gerhardt, G., Granholme, A-Ch., Mahalik, T.J., Seiger, A., Hoffer, B., and Olson, L., 1988, Intracerebral zenografts of human mesencephalic tissue into athymic rats: immunocytochemical and in vivo electrochemical studies, Proc. Nat. Acad. Sci., USA, 85, 8331–8334.Google Scholar
- 57.Stromberg, I., Bygdeman, M., Goldstein, M., Seiger, A, and Olson, L., 1986, Human substantia nigra grafted to the dopamine denervated striatum of immunosuppressed rats: evidence for functional reinnervation, Neurosci. Letters, 71, 271–276.Google Scholar
- 58.The use of foetuses and foetal material for research, 1972, The Peel Report, HMSO.Google Scholar
- 59.Thompson, W.G., 1890, Successful brain grafting, New York Med. J., 51, 701–702.Google Scholar
- 60.Webster, D.D., 1968, Critical analysis of the disability in Parkinson’s Disease, Mod. Treat., 5, 257–282.Google Scholar
- 61.Weiss, R., 1988, Forbidding fruits of foetal cell research, Science News, 134, 289–304.Google Scholar
- 62.Woodruff, M.F.A, Hitchcock, E.R., and Whitehead, V.L., 1977, Effect of C parvum and active specific immunotherapy on intracerebral transplantation of a murine fibrosarcoma, Br. J. Cancer, 35, 687–692.Google Scholar