Cytokine Induction in Vitro in Mouse Brain Endothelial Cells and Astrocytes by Exposure to Mouse Hepatitis Virus (MHV-4, JHM)
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Mouse hepatitis virus (MHV-4, JHM) is a neurotropic coronavirus which causes a spectrum of disease ranging from fatal encephalomyelitis to demyelination in susceptible murine hosts (1). Both direct infection of oligodendrocytes and immune-mediated events have been reported to play a role in the pathologic events in the central nervous system (CNS) following MHV-4 infection (2–5). The identification of CD8+ T-cells, NK cells, B-cells and PMN in the CNS of MHV-JHM infected mice suggests that immune mechanisms may be playing a role in the virus-induced disease process (3–9).