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Coronaviruses pp 443-448 | Cite as

Cytokine Induction in Vitro in Mouse Brain Endothelial Cells and Astrocytes by Exposure to Mouse Hepatitis Virus (MHV-4, JHM)

  • Jeymohan Joseph
  • James L. Grun
  • Fred D. Lublin
  • Robert L. Knobler
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 342)

Abstract

Mouse hepatitis virus (MHV-4, JHM) is a neurotropic coronavirus which causes a spectrum of disease ranging from fatal encephalomyelitis to demyelination in susceptible murine hosts (1). Both direct infection of oligodendrocytes and immune-mediated events have been reported to play a role in the pathologic events in the central nervous system (CNS) following MHV-4 infection (2–5). The identification of CD8+ T-cells, NK cells, B-cells and PMN in the CNS of MHV-JHM infected mice suggests that immune mechanisms may be playing a role in the virus-induced disease process (3–9).

Keywords

Endothelial Cell Cytokine Induction Mouse Hepatitis Virus Cerebral Endothelial Cell Lymphocytic Choriomeningitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Jeymohan Joseph
    • 1
  • James L. Grun
    • 2
  • Fred D. Lublin
    • 1
  • Robert L. Knobler
    • 1
  1. 1.Division of Neuroimmunology, Department of NeurologyJefferson Medical CollegePhiladelphiaUSA
  2. 2.Department of BiochemistryJefferson Medical CollegePhiladelphiaUSA

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