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Coronaviruses pp 137-142 | Cite as

Site-Specific Sequence Repair of Coronavirus Defective Interfering RNA by RNA Recombination and Edited RNA

  • Young-Nam Kim
  • Michael M. C. Lai
  • Shinji Makino
Chapter
  • 253 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 342)

Abstract

Mouse hepatitis virus (MHV), a coronavirus, contains an approximately 31 kb-long genomic RNA (8, 9). In MHV-infected cells, seven to eight species of virus-specific subgenomic mRNAs with a 3’-coterminal nested-set structure (6, 10) are synthesized; these are numbered 1 to 7, in decreasing order of size (6, 10). The 5’-end of MHV genomic RNA contains a 72- to 77-nucleotide-long leader sequence (5, 7, 22). An identical sequence is found at the 5’-end of each MHV mRNA species; in each, the leader sequence is fused with the mRNA body sequence, which starts from a consensus sequence at the intergenic sites (17, 21).

Keywords

Leader Sequence Nucleotide Deletion Helper Virus Virus Sample Mouse Hepatitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Baker, S. C., C.-K. Shieh, L. H. Soe, M.-F. Chang, D. M. Vannier, and M. M. C. Lai. J. Virol. 63:3693 (1989).PubMedGoogle Scholar
  2. 2.
    Baric, R. S., K. Fu, M. C. Schaad, and S. A. Stohlman. Virology 177:646 (1990).PubMedCrossRefGoogle Scholar
  3. 3.
    Fosmire, J. A., K. Hwang, and S. Makino. J. Virol. 66: 3522 (1992).PubMedGoogle Scholar
  4. 4.
    Jeong Y. S., and S. Makin. J. Virol. 66: 3339 (1992).PubMedGoogle Scholar
  5. 5.
    Lai, M. M. C., R. S. Banc, P. R. Brayton, and S. A. Stohlman. Proc. Natl. Acad. Sci. USA 81: 3626 (1984).PubMedCrossRefGoogle Scholar
  6. 6.
    Lai, M. M. C., P. R. Brayton, R. C. Armen, C. D. Patton, C. Pugh, and S. A. Stohlman. J. Virol. 39: 823 (1981).PubMedGoogle Scholar
  7. 7.
    Lai, M. M. C., C. D. Patton, R. S. Baric, and S. A. Stohlman. J. Virol. 46: 1027 (1983).PubMedGoogle Scholar
  8. 8.
    Lai, M. M. C., and S. A. Stohlman. J. Virol. 26: 236 (1978).PubMedGoogle Scholar
  9. 9.
    Lee, H.-J., C.-K. Shieh, A. E. Gorbalenya, E. V. Eugene, N. La Monica, J. Tuler, A. Bagdzhadzhyan, and M. M. C. Lai. Virology 180:567 (1991).PubMedCrossRefGoogle Scholar
  10. 10.
    Leibowitz, J. L., K. C. Wilhelmsen, and C. W. Bond. Virology 114: 39 (1981).PubMedCrossRefGoogle Scholar
  11. 11.
    Makin, S., N. Fujioka, and K. Fujiwara. J. Virol. 54:329 (1985).Google Scholar
  12. 12.
    Makin, S., J. G. Keck, S. A. Stohlman, and M. M. C. Lai. J. Virol. 57:729 (1986).Google Scholar
  13. 13.
    Makino, S., M. Joo, and J. K. Makino. J. Virol. 65.:6031 (1991).PubMedGoogle Scholar
  14. 14.
    Makin, S., and M. M. C. Lai. J. Virol. 63: 5285 (1989).Google Scholar
  15. 15.
    Makino, S., C.-K. Shieh, J. G. Keck, and M. M. C. Lai. Virology 163: 104 (1988).PubMedCrossRefGoogle Scholar
  16. 16.
    Makino, S., C.-K. Shieh, L. H. Soe, S. C. Baker, and M. M. C. Lai. Virology 166:550 (1988).PubMedCrossRefGoogle Scholar
  17. 17.
    Makino, S., L. H. Soe, C.-K. Shieh, and M. M. C. Lai. J. Viol. 62:3870 (1988).Google Scholar
  18. 18.
    Makino, S., F. Taguchi, N. Hirano, and K. Fujiwara. Virology 139: 138 (1984).PubMedCrossRefGoogle Scholar
  19. 19.
    Makin, S., K. Yokomori, and M. M. C. Lai. J. Virol. 64:6045 (1990).Google Scholar
  20. 20.
    McMaster, G. K., and G. G. Carmichael. Proc. Natl. Acad. Sci. USA 74:4835 (1977).PubMedCrossRefGoogle Scholar
  21. 21.
    Shieh, C.-K., L. H. Soe, S. Makino, M.-F. Chang, S. A. Stohlman, and M. M. C. Lai. Virology 156: 321 (1987).PubMedCrossRefGoogle Scholar
  22. 22.
    Spaan, W., H. Delius, M. Skinner, J. Armstrong, P. Rottier, S. Smeekens, B. A. M. van der Zeijst, and S. G. Siddell. EMBO J. 2: 1939 (1983).Google Scholar
  23. 23.
    van der Most, R. G., P. J. Bredenbeek, and W. J. M. Spaan. J. Virol. 65:3219 (1991).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Young-Nam Kim
    • 1
  • Michael M. C. Lai
    • 2
  • Shinji Makino
    • 1
  1. 1.Department of MicrobiologyThe University of Texas at AustinAustinUSA
  2. 2.Howard Hughes Medical Institute and Department of MicrobiologyUniversity of Southern California, School of MedicineLos AngelesUSA

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