In Vivo Pharmacokinetics of a Boron Neutron Capture Agent in a Tumor-Bearing Rat Via Boron-11 MRS and MRI

  • G. W. Kabalka
  • G. -Q. Cheng
  • C. Anderson
  • P. Bendel
  • P. Micca
  • D. N. Slatkin
Chapter

Abstract

We have developed boron-11 MRI and MRS techniques of potential use in boron neutron capture therapy (BNCT)1,2 for noninvasive quan tification and localization of BNCT agents such as the sodium salt of the dimer of the closododecaboranyl mercaptide anion, B24 H22 S2 4- (BSSB) 3.

Keywords

Boron Concentration Boron Neutron Capture Therapy Brookhaven National Laboratory Osmotic Pump Survey Image 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    G.W. Kabalka, M. Davis,and P. Bendel, Boron-11 MRI and MRS of Intact Animals Infused with a Boron-Neutron-Capture Agent, Magn. Reson. Med. 8: 89 (1988).PubMedCrossRefGoogle Scholar
  2. 2.
    P.Bendel, M. Davis, E. Berman, and G. W. Kabalka, A Method for ImagingNuclei with Short T2 Relaxation: Application to Boron-11 MR Imaging of a BNCT Agent in an Intact Rat, J. Magn. Res. 88: 369 (1990).Google Scholar
  3. 3.
    D. Slatkin, P. Micca, A. Forman, D. Gabel, L. Weilopolski, and R. Fairchild, Boron Uptake in Melanoma, Cerebrum,and Blood from Na2B12H11SH and Na4B24H22S2 Administered to Mice, Biochem. Pharmacol. 35: 1771 (1986).PubMedCrossRefGoogle Scholar
  4. 4.
    D. N.Slatkin, P. L. Micca, B. H. Laster, and R. G. Fairchild, Distri bution of Sulfhydryl Boranes in Mice and Rats, in: BNL-Report-51995. Brookhaven National Laboratories,Long Island (1986).Google Scholar
  5. 5.
    G.W. Kabalka, G.-Q. Cheng, P. Bendel, P.L. Micca, and D.N. Slatkin, In-Vivo Boron-11 MRI and MRS Using (B24H22S2)4- in the Rat, Magn. Reson. Imaging. 9:969 (1991).PubMedCrossRefGoogle Scholar
  6. 6.
    G.H. Glover, J.M. Pauley, and K.M. Bradshaw, Boron-11 Imaging with a 3-dimensional Reconstruction Method, J. Magn. Reson. Imaging. 2: 47(1992).PubMedCrossRefGoogle Scholar
  7. 7.
    H.H. Schmidek, S.L. Neilsen, A.L. Schiller, and J. Messer, Morphological Studies of Rat Brain Tumors Induced by N-Nitrosomethylurea, J. Neurosurg. 34: 335 (1971).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • G. W. Kabalka
    • 1
  • G. -Q. Cheng
    • 1
  • C. Anderson
    • 1
  • P. Bendel
    • 2
  • P. Micca
    • 3
  • D. N. Slatkin
    • 3
  1. 1.Departments of Radiology and ChemistryUniversity of TennesseeKnoxvilleUSA
  2. 2.Department of Chemical PhysicsWeizmann Institute of ScienceRehovotIsrael
  3. 3.Medical DepartmentBrookhaven National LaboratoryUptonUSA

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