Enantioselective Synthesis of an Unnatural Amino Acid, L-Carboranylalanine

  • Peggy A. Radel
  • Stephen B. Kahl
Chapter

Abstract

Boron neutron capture therapy (BNCT) holds great promise as a radiochemotherapeutic treatment for various cancers, including malignant melanoma and glioblastoma multiforme. Its appeal lies in the potential for great selectivity in cell killing due to its binary nature. A noncytotoxic compound containing 10B is first introduced to the tumor. Subsequent exposure to an epithermal neutron beam will cause a uniquely efficient neutron capture by 10B. The 11B intermediate undergoes rapid decomposition to an α-particle and recoil lithium atom. The sizeable kinetic energy of these particles (2.8 MeV) is deposited within 10-15 µm, roughly one cell diameter. The two independently manipulable requirements for this therapy allow great precision in treatment of neoplasms.

Keywords

Neutron Capture Boron Neutron Capture Therapy Peptide Analog Unnatural Amino Acid Benzyl Ester 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Peggy A. Radel
    • 1
  • Stephen B. Kahl
    • 1
  1. 1.Department of Pharmaceutical ChemistryUniversity of CaliforniaSan FranciscoUSA

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