A Proportion of Patients with Premature Ovarian Failure Show Lowered Percentages of Blood Monocyte Derived Dendritic Cells Capable of Forming Clusters with Lymphocytes

  • Annemieke Hoek
  • Yvonne van Kasteren
  • Meeny de Haan-Meulman
  • Joop Schoemaker
  • Hemmo A. Drexhage
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)

Abstract

Premature ovarian failure (POF) is characterized by an amenorrhea before the age of 40 years, estrogen deficiency and elevated levels of gonadotropins1. An autoimmune mechanism in the etiology of a proportion of POF patients is indicated by: 1. the presence of autoantibodies against ovarian cells2,3 and FSH receptors4,5, 2. a higher association of POF with other autoimmune endocrinopathies6,7,8, 3. lymphocytic and plasma cell infiltrates have been found in ovaries of POF patients9,10. Abnormalities in the cellular immune compartment have been described in these patients: increase in T-helper cells11, elevated percentage of peripheral blood HLA-dr+ T-cells12.

Keywords

Postmenopausal Woman Peripheral Blood Monocyte Premature Ovarian Failure Allogeneic Lymphocyte Blood Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Annemieke Hoek
    • 1
    • 2
  • Yvonne van Kasteren
    • 1
  • Meeny de Haan-Meulman
    • 2
  • Joop Schoemaker
    • 1
  • Hemmo A. Drexhage
    • 2
  1. 1.Department of Gynaecology and ObstetricsFree UniversityAmsterdamThe Netherlands
  2. 2.Department of ImmunologyErasmus University RotterdamThe Netherlands

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