Vaccination with Tumor Antigen-Pulsed Dendritic Cells Induces in Vivo Resistance to A B Cell Lymphoma
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Abstract
The role of the immune system in tumor surveillance is still a matter of speculation. Immune responses to murine experimental tumors have led to the unequivocal identification of tumor-associated antigens (TAA) which can become the target of rejection mechanisms (1). However, studies of 27 different tumors, all of strictly spontaneous origin, have revealed no evidence of tumor immunogenicity (2). It is therefore still unclear whether the lack of an efficient immune response able to eradicate the tumor is due to a lack of expression of TAA or to a suppressor mechanism that inhibits an ongoing immune response.
Keywords
Dendritic Cell Chronic Lymphocytic Leukemia IgG2a Antibody Prolymphocytic Leukemia Inhibit Cytokine Production
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