My Half-Life in Teratology

A Key to Cancer Etiology
  • Robert W. Miller

Abstract

My career has been by drift rather than by design. Research was not even in my mind when I graduated from medical school. In each new venture since then I tried to build on what had gone before, not wasting any of it: training in medicine, then pediatrics, followed by the study of radiation effects, epidemiology, teratogenesis, and carcinogenesis. For 30 years my professional life has been in cancer etiology, with a good portion devoted to teratology. Here is an account of the teratologic half.

Keywords

Congenital Malformation Childhood Cancer Cancer Etiology Propionic Acidemia Minamata Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Allen, R. W., Jr., Ogden, B., Bentley, F. L., and Jung, A. L. 1980. Fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease in neonate. J. Am. Med. Assoc. 244:1464–1465.CrossRefGoogle Scholar
  2. Bader, J. L., Miller, R. W., Meadows, A. T., Zimmerman, L. E., Champion, L. A. A., and Voute, P. A. 1980. Trilateral retinoblastoma. Lancet 2:582–583.PubMedCrossRefGoogle Scholar
  3. Bader, J. L., Meadows, A. W., Zimmerman, L. E., Voute, P. A., Champion, L. A. A., and Miller, R. W. 1982. Bilateral retinoblastoma with intracranial retinoblastoma: trilateral retinoblastoma. Cancer Genet. Cytogenet. 5:203–213.PubMedCrossRefGoogle Scholar
  4. Bodmer, W. F., Bailey, C. J., Bodmer, J., Bussey, H. J. R., Ellis, A., Gorman, P., Lucibello, F. C., Murday, V. A., Rider, S. H., Scambler, P., Sheer, D., Solomon, E., and Spurr, N. K. 1987. Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature 328:614–616.PubMedCrossRefGoogle Scholar
  5. Centers for Disease Control. 1988a. Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in US Army Vietnam-era veterans. J Am. Med. Assoc. 260:1249–1254.CrossRefGoogle Scholar
  6. Centers for Disease Control. 1988b. Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in air force health study participants—preliminary report. Morbid. Mortal. Weekly Rep. 37:309–311.Google Scholar
  7. Committee on Environmental Hazards, American Academy of Pediatrics. 1968. Conference on the pédiatrie significance of peacetime radioactive fallout. Pediatrics 41:165–378.Google Scholar
  8. Committee on Environmental Hazards, American Academy of Pediatrics. 1974. The susceptibility of the fetus and child to chemical pollutants. Pediatrics 53:775–862.Google Scholar
  9. Committee on Environmental Hazards, American Academy of Pediatrics. 1982. Chemical and Radiation Hazards to Children, Ross Conference on Pediatrics Research. Ross Laboratories, Columbus, Ohio.Google Scholar
  10. Curley, A., Hawk, R. E., Kimbrough, R. D., Nathenson, G., and Finberg, L. 1971. Dermal absorption of hexachlorophane in infants. Lancet 2:296–297.PubMedCrossRefGoogle Scholar
  11. Fraumeni, J. F., Jr., and Miller, R. W. 1967. Epidemiology of human leukemia: recent observations. J. Natl Cancer Inst. 38:593–605.PubMedGoogle Scholar
  12. Glass, A. G., and Fraumeni, J. F., Jr. 1970. Epidemiology of bone cancer in children. J. Natl. Cancer Inst. 44:187–199.PubMedGoogle Scholar
  13. Goldgar, D. E., Green P., Parry, D. M., and Mulvihill, J. J. 1989. Multipoint linkage analysis in neurofibromatosis type 1: an international collaboration. Am. J. Hum. Genet. 44:6–12.PubMedGoogle Scholar
  14. Gough, M. 1986. Dioxin, Agent Orage: The Facts. Plenum Press, New York.Google Scholar
  15. Grundy, P., Koufos, A., Morgan, K., Li, F. P., Meadows, A. T., and Cavenee, W. K. 1988. Familial predisposition to Wilms’ tumour does not map to the short arm of chromosome 11. Nature 336:374–376.PubMedCrossRefGoogle Scholar
  16. Harada, M. 1978. Congenital Minamata disease: intrauterine methylmercury poisoning. Teratology 18:285–288.PubMedCrossRefGoogle Scholar
  17. Hecht, F., Koler, R. D., Rigas, D. A., Dahnke, G. S., Case, M. P., Tisdale, V., and Miller, R. W. 1966. Leukaemia and lymphocytes in ataxia-telangiectasia. Lancet 2:1193.CrossRefGoogle Scholar
  18. Hecht, F., McCaw, B. K., and Koler, R. D. 1973. Ataxia-telangiectasia: clonal growth of translocation lymphocytes. N. Engl. J. Med. 289:286–291.PubMedCrossRefGoogle Scholar
  19. Hecht, F., Hecht, B. K., Northrup, J. C., Trachtenberg, N., Wood, T. S., and Cohen, J. D. 1982. Genetics of familial neuroblastoma: Long-range studies. Cancer Genet. Cytogenet. 7(3):227–230.PubMedCrossRefGoogle Scholar
  20. Hoover, R. 1977. Immunosuppression, in: Origins of Human Cancer, H. H. Hiatt, J. D. Watson, and J. A. Winsten, eds. Cold Spring Harbor Laboratory, Cold Spring Harbor, N. Y., pp. 369–379.Google Scholar
  21. Huebner, R. J., and Todaro, G. J. 1969. Oncogenes of RNA tumor viruses as determinants of cancer. Proc. Natl. Acad. Sci. USA 64:1087–1094.PubMedCrossRefGoogle Scholar
  22. International Commission on Radiological Protection. 1986. Developmental Effects of Irradiation on the Brain of the Embryo and Fetus. ICRP Publ. 49, Pergamon Press, Elmsford, N. Y.Google Scholar
  23. Jensen, R. D., and Miller, R. W. 1971. Retinoblastoma: epidemiologic characteristics. N. Engl. J. Med. 285:307–311.PubMedCrossRefGoogle Scholar
  24. Knudson, A. G. 1971. Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 68:820–823.PubMedCrossRefGoogle Scholar
  25. Knudson, A. G., and Strong, L. C. 1972. Mutation and cancer: a model for Wilms’ tumor of the kidney. J. Natl. Cancer Inst. 48:313–324.PubMedGoogle Scholar
  26. Lessard, E. T., Brill, A. B., and Adams, W. H. 1986. Thyroid cancer in the Marshallese: relative risk of short-lived internal emitters and external radiation exposure, in: Fourth International Radiopharmaceutical Dosimetry Conference, A. T. Schlafke-Stelson and E. E. Watson, eds., Oak Ridge Associated Universities, Oak Ridge, Tenn., pp. 628–647.Google Scholar
  27. Li, F. P. 1988. Cancer families: human models of susceptibility to neoplasia. Cancer Res. 48:5381–5386.PubMedGoogle Scholar
  28. Li, F. P., and Fraumeni, J. F., Jr. 1969. Soft-tissue sarcomas, breast cancer, and other neoplasms: a familial syndrome? Ann. Intern. Med. 71:747–752.PubMedGoogle Scholar
  29. Li, F. P., and Jaffe, N. 1974. Progeny of childhood cancer survivors. Lancet 2:707–709.PubMedCrossRefGoogle Scholar
  30. Li, F. P., Fraumeni, J. F., Jr., Mulvihill, J. J., Blattner, W. A., Dreyfus, M. G., Tucker, M. A., and Miller, R. W. 1988. A cancer family syndrome in twenty-four kindreds. Cancer Res. 48:5358–5362.PubMedGoogle Scholar
  31. Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Jr., Nelson, C. E., Kim, D. H., Kassei, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A. and Friend, S. H. 1990. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250:1253–1238.CrossRefGoogle Scholar
  32. Martin-Bouyer, G., Lebreton, R., Toga, M., Stolley, P. D., and Lockhart, J. 1982. Outbreak of accidental hexachlorophene poisoning in France, Lancet 1:91–95.PubMedCrossRefGoogle Scholar
  33. Matsumoto, H., and Takeuchi, T. 1965. Minamata disease, a neurological study of two cases of intrauterine intoxication by a methyl mercury compound. J. Neuropathol. Exp. Neurol. 24:563–574.PubMedCrossRefGoogle Scholar
  34. Miller, R. W. 1953. Some potential hazards of the use of roentgen rays in pediatrics. Pediatrics 11:294–303.PubMedGoogle Scholar
  35. Miller, R. W. 1956. Delayed effects occurring within the first decade after exposure of young individuals to the Hiroshima atomic bomb. Pediatrics 18:1–18.PubMedGoogle Scholar
  36. Miller, R. W. 1963a. Distant visual acuity loss among Japanese grammar school children: the roles of heredity and the environment. J. Chronic. Dis. 16:31–54.CrossRefGoogle Scholar
  37. Miller, R. W. 1963b. Down’s syndrome (mongolism), other congenital malformations and cancers among the sibs of leukemia children. N. Engl. J. Med. 268:393–401.CrossRefGoogle Scholar
  38. Miller, R. W. 1964. Radiation, chromosomes and viruses in the etiology of leukemia: evidence from epidemiologic research. N. Engl. J. Med. 271:30–36.PubMedCrossRefGoogle Scholar
  39. Miller, R. W. 1966. Relation between cancer and congenital defects in man. N. Engl.J. Med. 275:87–93.PubMedCrossRefGoogle Scholar
  40. Miller, R. W. 1968. Deaths from childhood cancer in sibs. N. Engl.J. Med. 279:122–126.PubMedCrossRefGoogle Scholar
  41. Miller, R. W. 1969. Childhood cancer and congenital defects: a study of U. S. death certificates during the period 1960-1966. Pediatr. Res. 3:389–397.PubMedCrossRefGoogle Scholar
  42. Miller, R. W. 1970. Teratology in 1970: the national scene: President’s report to the Teratology Society. Teratology 3:223–227.PubMedCrossRefGoogle Scholar
  43. Miller, R. W. 1971a. Deaths from childhood leukemia and solid tumors among twins and other sibs in the United States, 1960-67. J. Natl. Cancer Inst. 46:203–209.PubMedGoogle Scholar
  44. Miller, R. W. 1971b. Relation between cancer and congenital malformations: the value of small series, with the note on pineal tumors in native and migrant Japanese. Isr.J. Med. Sci. 7:1461–1464.PubMedGoogle Scholar
  45. Miller, R. W. 1971c. Cola-colored babies: chlorobiphenyl poisoning in Japan. Teratology 4:211–212.CrossRefGoogle Scholar
  46. Miller, R. W. 1972. Interim report: UICC international study of childhood cancer. Int. J. Cancer 10:675–677.PubMedCrossRefGoogle Scholar
  47. Miller, R. W. 1976. Dried human umbilical cords and study of pollutants. Lancet 1:315–316.PubMedCrossRefGoogle Scholar
  48. Miller, R. W. 1977. Ethnic differences in cancer occurrence: genetic and environmental influences with particular reference to neuroblastoma, in: Genetics of Human Cancer, J. J. Mulvihill, R. W. Miller, and J. F. Fraumeni, Jr., eds. Raven Press, New York, pp. 1–14.Google Scholar
  49. Miller, R. W. 1982. Chemical and radiation hazards to children: highlights of a meeting. J. Pediatr. 101:495–497.PubMedCrossRefGoogle Scholar
  50. Miller, R. W. 1985. Congenital PCB poisoning: a réévaluation. Environ. Health Perspect. 60:211–214.PubMedCrossRefGoogle Scholar
  51. Miller, R. W. 1988. Prenatal effects of exposure to ionizing radiation. J. Wash. Acad. Sci. 78:94–100.Google Scholar
  52. Miller, R. W., and Nishimura, H. 1966. Congenital malformations and cancer: United States-Japan Cooperative Science Program. Science 151:357–358.PubMedCrossRefGoogle Scholar
  53. Miller, R. W., Fraumeni, J. F., Jr., and Manning, M. D. 1964. Association of Wilms’ tumor with aniridia, hemihypertrophy and other congenital malformations. N. Engl. J. Med. 270:922–927.PubMedCrossRefGoogle Scholar
  54. Miller, R. W., Watanabe, S., Fraumeni, J. F., Jr., Sugimura, T., Takayama, S. and Sugano, H., eds. 1988. Unusual Occurrences as Clues to Cancer Etiology. Proceedings of the 18th Princess Takamatsu Cancer Research Fund Symposium. Taylor & Francis, London.Google Scholar
  55. Mocarelli, P. Needham, L. L., Marocchi, A., Patterson, D. G., Jr., Brambilla, P., Gerthoux, P. M., Meazza, L., and Carreri, V. 1991. Serum concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin and test results from selected residents of Seveso, Italy. J. Toxicol. Environ. Health. 32(4):357–366.PubMedCrossRefGoogle Scholar
  56. Mulvihill, J. J. 1972. Congenital and genetic disease in domestic animals. Science 176:132–137.PubMedCrossRefGoogle Scholar
  57. Mulvihill, J. J., Miller, R. W., and Fraumeni, J. F., Jr., eds. 1977. Genetics of Human Cancer. Raven Press, New York.Google Scholar
  58. Mulvihill, J. J., Parry, D. M., Sherman, J. L., Pikus, A., Kaiser-Kupfer, M. I., and Eldridge, R. 1990. Neurofibromatosis 1 (Reckinghausen disease) and neurofibromatosis 2 (bilateral acoustic neurofibromatosis): an update. Ann. Intern. Med. 113:39–52.PubMedGoogle Scholar
  59. Neel, J. V., and Schull, W. J. 1956. The Effect of Exposure to the Atomic Bombs on Pregnancy Termination in Hiroshima and Nagasaki. National Academy of Sciences, Washington, D. C.Google Scholar
  60. Nishigaki, S., and Harada, M. 1975. Methylmercury and selenium in umbilical cords of inhabitants of the Minamata area. Nature 258:324–325.PubMedCrossRefGoogle Scholar
  61. Nishimura, H., and Miller, J. R., eds. 1969. Methods for Teratological Studies in Experimental Animals and Man. Proceedings of the Second International Workshop in Teratology, Kyoto, 1968. Igaku Shoin, Tokyo.Google Scholar
  62. Nora, A. H., and Nora, J. J. 1975. A syndrome of multiple congenital anomalies associated with teratogenic exposure. Arch. Environ. Health 30:17–21.PubMedGoogle Scholar
  63. O’Conor, G. T. 1988. Malignant lymphoma in African children: three decades of discovery, in: Unusual Occurrences as Clues to Cancer Etiology. Proceedings of the 18th Princess Takamatsu Cancer Research Fund Symposium, R. W. Miller, S. Watanabe, J. F. Fraumeni, Jr., T. Sugimura, S. Takayama, and H. Sugano, eds. Taylor & Francis, London, pp. 137–147.Google Scholar
  64. Pegelow, C. H., Ebbin, A. J., Powars, D., and Towner, J. W. 1975. Familial neuroblastoma. J. Pediatr. 87:763–765.PubMedCrossRefGoogle Scholar
  65. Plummer, G. 1952. Anomalies occurring in children exposed in utero to the atomic bomb in Hiroshima. Pediatrics 10:687–693.PubMedGoogle Scholar
  66. Priester, W. A., and McKay, F. W. 1980. The Occurrence of Tumors in Domestic Animals. Natl. Cancer Inst. Monogr. 54:1–210.PubMedGoogle Scholar
  67. Priester, W. A., and Mantel, N. 1971. Occurrence of tumors in domestic animals: data from 12 United States and Canadian colleges of veterinary medicine. J. Natl. Cancer Inst. 47:1333–1344.PubMedGoogle Scholar
  68. Riccardi, V. M., and Mulvihill, J. J., eds. 1981. Neurofibromatosis (von Recklinghausen Disease): Genetics, Cell Biology, and Biochemistry. Raven Press, New York.Google Scholar
  69. Rogan, W. J., Gladen, B. C., Hung, K.-L., Koong, S.-L., Shih, L.-Y., Taylor, J. S., Wu, Y.-C, Yang, D., Ragan, N. B., and Hsu, C.-C. 1988. Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science 341:334–336.CrossRefGoogle Scholar
  70. Schottenfeld, D., and Fraumeni, J. F., Jr. 1982. Cancer Epidemiology and Prevention. Saunders, Philadelphia.Google Scholar
  71. Shepard, T. H., Miller, J. R., and Marois, M., eds. 1975. Methods for Detection of Environmental Agents that Produce Congenital Defects. Proceedings of the Guadeloupe Conference Sponsored by l’Institut de la Vie. American Elsevier, New York.Google Scholar
  72. Siraganian, P. A., Miller, R. W., and Swender, P. T. 1987. Cystic fibrosis and ileal carcinoma. Lancet 2:1158.PubMedCrossRefGoogle Scholar
  73. Taylor, A. M. R., Harnden, D. G., Arlett, C. F., Harcourt, S. A., Lehmann, A. R., Stevens, S., and Bridges, B. A. 1975. Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity. Nature 258:427–429.PubMedCrossRefGoogle Scholar
  74. Wolfe, W. H., Michalek, J. E., Miner, J. C., and Rahe, A. J. 1992. An Epidemiologic Investigation of Health Effects in Air Force Personnel following Exposures to Herbicides: Reproductive Outcomes. Epidemiologic Research Division, Armstrong Laboratory, Human Systems Center, Brooks Air Force Base, Texas.Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Robert W. Miller
    • 1
  1. 1.Clinical Epidemiology BranchNational Cancer InstituteBethesdaUSA

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