Regulation of Ribosomal Protein mRNA Translation in Bacteria

The Case of S15
  • Claude Portier
  • Marianne Grunberg-Manago


Ribosomal proteins (r-proteins) bind to specific sites on ribosomal RNA (rRNA) to assemble a ribosome. Except for L12/L7, there is always a stoichiometric amount of all r-proteins and rRNA and the amount of free ribosomal proteins is low in the cell. Thus a coordinated regulation must exist. For the vast majority of ribosomal proteins, the mechanism of coordinate expression is at the translational autoregulation level. Some exceptions to this rule are observed, e.g., in the S10 operon (regulated both by transcription attenuation and translation inhibition1), the spc operon,2 and the trmD operon (nonautoregulated).3,4 In most cases, each operon encoding a ribosomal protein encodes a ribosomal protein repressor (Fig. 1). This repressor binds generally specifically to the 5′ region of the messenger and stops the translation of all downstream cistrons. This phenomenon, called translational coupling, has been demonstrated for the Lll-L1 operon.


Ribosomal Protein Tobacco Mosaic Virus Ribosome Binding Site Pseudoknot Structure Turnip Yellow Mosaic Virus 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Claude Portier
    • 1
  • Marianne Grunberg-Manago
    • 1
  1. 1.Institut de Biologie Physico-ChemiqueParisFrance

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