Activation Mechanisms of Phospholipase C Isozymes

  • Sue Goo Rhee
Chapter
Part of the NATO ASI Series book series (NSSA, volume 246)

Abstract

On binding to their cell surface receptors, many extracellular signaling molecules including hormones, peptide growth factors, neurotransmitters and immunoglobulins, elicit intracellular responses by activating inositol phospholipid-specific phospholipase C (PLC).1 Activated PLC catalyzes the hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) to generate diacylglycerol and inositol 1, 4, 5-trisphosphate (IP3). Diacylglycerol is the physiological activator of protein kinase C (PKC) and IP3 induces the release of Ca2+ from internal stores.1 This bifurcating pathway constitutes the cornerstone of a transmembrane signal transduction mechanism that is now known to regulate a large array of cellular processes, including metabolism, secretion, contraction, neural activity, and proliferation.

Keywords

Nerve Growth Factor Tyrosine Phosphorylation Mutant Epidermal Growth Factor Receptor Inositol Phosphate Formation Mutant Epidermal Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Sue Goo Rhee
    • 1
  1. 1.Laboratory of Biochemistry National Heart, Lung and Blood InstituteNational Institutes of HealthBethesdaUSA

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