Purine and Pyrimidine Metabolisms in Human Gliomas, Melanomas and Colon Carcinomas Xenografts, Relation to their Cytogenetic Profile

  • V. Bardot
  • A. M. Dutrillaux
  • J. Beaumatin
  • D. Lefrançois
  • F. Apiou
  • B. Dutrillaux
  • C. Luccioni
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 370)

Abstract

Cytogenetic analyses performed on human solid tumors have shown, for some of them characteristic patterns of chromosomes anomalies. To understand the meaning of recurrent chromosomal imbalances, it was postulated that they could be related to specific metabolic modifications. This hypothesis was first tested on colorectal carcinomas1, 2, 3 and verified on gliomas, by comparing tumor samples to corresponding normal tissue4, 5. In an attempt to precise the role of chromosomal aberrations, it appeared of interest to develop a metabolic study of three tumors, presenting either similar or distinct cytogenetic patterns, in order to compare their metabolic patterns.

Keywords

Thymidine Kinase Human Glioma Adenylate Kinase Purine Metabolism Pyrimidine Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • V. Bardot
    • 1
  • A. M. Dutrillaux
    • 2
  • J. Beaumatin
    • 1
  • D. Lefrançois
    • 2
  • F. Apiou
    • 2
  • B. Dutrillaux
    • 2
  • C. Luccioni
    • 1
  1. 1.Commissariat à l’Energie AtomiqueDSV/DPTE/LCGFontenay aux Roses cedexFrance
  2. 2.URA 620 CNRS, Section BiologieInstitut CurieParis cedex 05France

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