Purine Metabolism in Female Patients with Primary Gout

  • Juan G. Puig
  • Felícitas A. Mateos
  • Ma. E. Miranda
  • Rosa J. Torres
  • Eugenio de Miguel
  • Carlos Pérez de Ayala
  • Antonio Gil
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 370)

Abstract

Uncontrolled studies have shown that mean serum urate levels are higher in female patients with gout than in gouty male patients (1–5) and that daily uric acid excretion is similar (4) or lower (3, 5) in the former than in the latter. These findings prompted the hypothesis that female patients with primary gout have a more defective tubular transport of uric acid than gouty male patients (3). In this prospective study, carried out under controlled conditions, we examined purine metabolism in female patients with primary gout. In addition, we investigated whether there are sex-related differences in purine metabolism among patients with primary gout.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Juan G. Puig
    • 1
  • Felícitas A. Mateos
    • 2
  • Ma. E. Miranda
    • 1
  • Rosa J. Torres
    • 2
  • Eugenio de Miguel
    • 3
  • Carlos Pérez de Ayala
    • 3
  • Antonio Gil
    • 1
  1. 1.Division of Internal Medicine, “La Paz” HospitalUniversidad AutónomaMadridSpain
  2. 2.Division of Clinical Biochemistry, “La Paz” HospitalUniversidad AutónomaMadridSpain
  3. 3.Division of Rheumatology, “La Paz” HospitalUniversidad AutónomaMadridSpain

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