International Meetings on Arterial Chemoreceptors: Historical Perspectives

  • R. G. O’Regan
  • P. Nolan
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 360)

Abstract

The progression of knowledge in a field of scientific research can be aptly chronicled by a study of the records of scientific meetings on that topic. This review describes the highlights of the first 8 international meetings on arterial chemoreception, and as such provides an interesting historical view of the developments in carotid body research since the 1950’s. The success of these meetings culminated in the formation of the International Society for Arterial Chemoreception (ISAC) in 1988. This marked the beginning of a new era with more frequent meetings held within a formal international organizational structure. Four meetings have been held under the auspices of the Society, including the 12th International meeting held in Dublin in September 1993, the proceedings of which form this volume. These meetings are such recent events, and included such a large volume of scientific work, that it would be impossible to accurately describe their place in the history of chemoreceptor research. For this reason, this chapter concentrates largely on the earlier meetings. There is a danger that a review such as this could become a mere catalogue of brief abstracts. Therefore, the focus of this chapter has been further narrowed so that particular attention is paid to work which was the source of controversy or papers which opened new horizons in chemoreceptor research. As a consequence, many excellent experiments and experimenters are not mentioned. We hope, however, that this description of the importance of scientific meetings in the development of carotid body research, while mentioning relatively few individuals, will be taken as a tribute to all those who have participated in such meetings over the years.

Keywords

Carotid Body Glomus Cell Peripheral Chemoreceptor Arterial Chemoreception Plasma Skimming 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Acker, H., Weigelt, H., Lubbers, D.W., Bingmann, D. & Caspers, H. (1976) Effect of changes in Ca++ and K+ activity upon tissue PO2 and chemoreceptor activity of the cat carotid body. In “Morphology and Mechanisms of Chemoreceptors.” A.S. Paintal, ed., Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India, pp. 103–112Google Scholar
  2. Acker, H. &Lubbers, D.W. (1977) Relationship between local flow, tissue PO2 and total flow of the cat carotid body. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany, pp 271–276CrossRefGoogle Scholar
  3. Anichkov, S.V. &Belen’Kii, M.L. (1963) “Pharmacology of the Carotid Body Chemoreceptors” Permagon, Oxford, UK.Google Scholar
  4. Band, D.M. &Semple, S.J.G. (1967) Continuous measurement of blood pH with an indwelling glass electrode. J. Appl. Physiol. 22:854–857PubMedGoogle Scholar
  5. Band, D.M., Willshaw, P. &Wolff, C.B. (1976) The speed of response of the carotid body chemoreceptor. In “Morphology and Mechanisms of Chemoreceptors.” A.S. Paintal, ed., Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. pp. 197–208Google Scholar
  6. Belmonte, C., Gonzalez, C. &Garcia, A.G. (1977) Dopamine beta-hydroxylase activity in the cat carotid body. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany, pp 99–105CrossRefGoogle Scholar
  7. Bingmann, D., Kienecker, E.-W. &Knoche, H. (1977) Chemoreceptor activity in the rabbit carotid sinus nerve during regeneration. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany. pp 36–43CrossRefGoogle Scholar
  8. Bingmann, D., Kienecker, E.W., Caspers, H., &Knoche, H. (1981a) Chemoreceptor activity of sinus nerve fibres after their implantation into the wall of the external carotid artery. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 92–104Google Scholar
  9. Bingmann, D., Kienecker, E.W., Caspers, H., &Knoche, H. (1981) Receptive properties of regenerating sinus nerve endings in the wall of the external carotid artery. In “Arterial Chemoreceptors”, C. Belmonte, DJ. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 105–114Google Scholar
  10. Biscoe, T.J., Lall, A. &Sampson, S.R. (1970) Electron microscopic and electrophysiological studies on the carotid body following intracranial section of the glossopharyngeal nerve. J. Physiol. 208:133–152PubMedGoogle Scholar
  11. Biscoe, T.J. &Purves, M.J. (1967) Observations on the rhythmic variation in the cat carotid body chemoreceptor activity which has the same period as respiration. J. Physiol. 190:389–412PubMedGoogle Scholar
  12. Blanco, C.E., Hanson, M.A., McCooke, H.B. &B.A. Williams (1987a) The effect of premature delivery on chemoreceptor sensitivity in the lamb. In “Chemoreceptors in Respiratory Control”, J.A. Ribeiro &D.J. Pallot, eds., Croom Helm, Kent, UK. pp 216–220CrossRefGoogle Scholar
  13. Blanco, C.E., Hanson, M.A., McCooke, H.B. &B.A. Williams (1987b) Studies of chemoreceptor resetting after hyperoxic ventilation of the fetus in utero. In “Chemoreceptors in Respiratory Control”, J.A. Ribeiro &DJ. Pallot, eds., Croom Helm, Kent, UK. pp 221–227CrossRefGoogle Scholar
  14. Cunningham, D.J.C. &Drysdale, D.B. (1976) The role of human arterial chemoreceptors in normal respiratory regulation, and some factors which may influence the responses to dynamic stimulation. In “Morphology and Mechanisms of Chemoreceptors.” A.S. Paintal, ed., Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. pp. 209–221Google Scholar
  15. Dawes, G.S., Hanson, M.A., Holman, R.B. &McCooke, H.B. (1984) Preliminary observations on the concentrations of catecholamines and their metabolites in the carotid bodies of newborn lambs. In “The Peripheral Arterial Chemoreceptors”, D.J.Pallot, ed., Croom Helm, London, UK. pp 365–372Google Scholar
  16. de Castro, F. (1951) Sur la structure de la synapse dans les chemocepteurs: leur mechanisme d’excitation et role dans la circulation sanguine locale. Acta. Physiol. Scand. 22:14–43CrossRefGoogle Scholar
  17. Delpiano, M.A. &Acker, H. (1984) The extracellular Ca++ and K+ activities in the cat carotid body and their relationship to chemoreception. In “The Peripheral Arterial Chemoreceptors”, D.J.Pallot, ed., Croom Helm, London, UK. pp 101–110Google Scholar
  18. Dinger, B.G., Stenaas, L.J. &Fidone S.J. (1984) Chemosensory end organs re-innervated by normal and foreign nerves. In “The Peripheral Arterial Chemoreceptors”, D.J.Pallot, ed., Croom Helm, London, UK. ppGoogle Scholar
  19. Douglas, W.W. (1952) The effect of a ganglion-blocking drug, hexamethonium, on the response of the cat’s carotid body to various stimuli. J. Physiol. 118:373–383PubMedGoogle Scholar
  20. Dutton, R.E. &Permutt, S. (1968) Ventilatory responses to transient changes in carbon dioxide. In “Arterial Chemoreceptors.”, R.W. Torrance, ed.. Blackwell, Oxford, UK, pp 373–385Google Scholar
  21. Edelman, N.H., T.V. Santiago &Doblar, D. (1976) Mechanism of the ventilatory response to carbon monoxide of unanaesthetized goats. In “Morphology and Mechanisms of Chemoreceptors.” A.S. Paintal, ed., Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. pp. 317–326Google Scholar
  22. Eden, G.J. &Hanson, M.A. (1987) Effects of chronic hypoxia on chemoreceptor function in the newborn. In “Chemoreceptors in Respiratory Control”, J.A. Ribeiro &D.J. Pallot, eds., Croom Helm, Kent, UK. pp 369–CrossRefGoogle Scholar
  23. Eyzaguirre, C. (1981) An overview of mechanisms associated with the onset of sensory discharges in the carotid nerve. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 20–44Google Scholar
  24. Eyzaguirre, C. &Zapata, P. (1968) A discussion of possible transmitter or generator substances in carotid body chemoreceptors. In “Arterial Chemoreceptors.”, R.W. Torrance, ed., Blackwell, Oxford, UK, pp 213–251Google Scholar
  25. Eyzaguirre, C., Monti-Bloch, L. &Hayashida, Y. (1984) The effects of putative neurotransmitters on the glomus cell membrane and carotid nerve discharges. In “The Peripheral Arterial Chemoreceptors”, D.J.Pallot, ed., Croom Helm, London, UK. pp 373–382Google Scholar
  26. Fidone, S.J. &Sato, A. (1970) Efferent inhibition and antidromic depression of chemoreceptor A-fibres from the cat carotid body. Brain Res. 22:181–193PubMedCrossRefGoogle Scholar
  27. Fidone, S., Gonzalez, C. &Yoshikazi, K. (1981) A study of the relationship between dopamine release and chemosensory discharge from rabbit carotid body in vitro: preliminary findings. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 209–219Google Scholar
  28. Fitzgerald, R.S. (1976) Single fiber chemoreceptor responses of carotid and aortic bodies. In “Morphology and Mechanisms of Chemoreceptors.” A.S. Paintal, ed., Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. pp. 27–35Google Scholar
  29. Fitzgerald, R.S., Traystman, R.J., Sylvester, J.T. &Permutt, S. Comparison of the effects of hypoxic hypoxia and carbon monoxide: a review. In “Morphology and Mechanisms of Chemoreceptors.” A.S. Paintal, ed., Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. pp. 327–334Google Scholar
  30. Gallego, A. (1981) Fernando de Castro: contributions to the discovery and study of the vascular baroreceptors and the blood chemoreceptors. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 1–19Google Scholar
  31. Gonzalez, C., Kwok, Y., Gibb, J. &Fidone, S. (1981a) Regulation of tyrosine hydroxylase activities in carotid body, superior cervical ganglion and adrenal gland of rat rabbit and cat. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 187–197Google Scholar
  32. Gonzalez, C., Yoskikazi, Y. &Fidone, S. (1981b) Catecholamine synthesis from tyrosine and dopa in rabbit carotid body: effects of natural stimulation. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 198–208Google Scholar
  33. Gonzalez, E., Rigual, R., Gonzalez, C. &Fidone, S. (1984) Uptake and metabolism of dopamine by the carotid body. In “The Peripheral Arterial Chemoreceptors”, D.J.Pallot, ed., Croom Helm, London, UK. ppGoogle Scholar
  34. Goodman, N.W. (1975) Efferent inhibition of arterial chemoreceptors and stimulation of the sinus nerve. In “The Peripheral Arterial Chemoreceptors” M.J. Purves, ed., Cambridge University Press, London, UK, pp. 241–251Google Scholar
  35. Gordon, B.H., Pallot, D.J., Mir, A., Ings, R.M.J., Evrard, Y. &Campbell, D.B. (1987) Kinetics of almitrine bismesylate and its metabolites in the carotid body and other tissues of the rat. In “Chemoreceptors in Respiratory Control”, J.A. Ribeiro &D.J. Pallot, eds., Croom Helm, Kent, UK. pp 394–407CrossRefGoogle Scholar
  36. Grant, B. &Semple, S J.G. (1976) Mechanisms whereby oscillations in arterial carbon dioxide tension might affect pulmonary ventilation. In “Morphology and Mechanisms of Chemoreceptors.” A.S. Paintal, ed., Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. pp. 191–208Google Scholar
  37. Gronblad, M. &Korkola, O. (1977) Loss of histochemically demonstrable catecholamines in the glomus cells of the carotid body after α-methylparatyrosine treatment. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany. pp 130–135CrossRefGoogle Scholar
  38. Hanbauer, I. (1977) Molecular biology of chemoreceptor function: induction of tyrosine hydroxylase in the rat carotid body elicited by hypoxia. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany. pp 114–121CrossRefGoogle Scholar
  39. Hanson, M.A., Nye, P.C.G., &Torrance, R.W. (1981) The exodus of an extracellular bicarbonate theory and the genesis of an intracellular one. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 417–429Google Scholar
  40. Horn, N.M., Hasan, F.F. &Waters, R. (1984) Dopamine receptors in the peripheral chemoreceptors of the rat. In “The Peripheral Arterial Chemoreceptors”, D.J.Pallot, ed., Croom Helm, London, UK. pp 345–352Google Scholar
  41. Heath, D., Smith, P. &Hurst, G. (1987) The carotid bodies in coarctation of the aorta. In “Chemoreceptors in Respiratory Control”, J.A. Ribeiro &D.J. Pallot, eds., Croom Helm, Kent, UK. pp 247.253CrossRefGoogle Scholar
  42. Hellstrom, S. (1977) Effects of hypoxia on carotid body type I cells and their catecholamines. A biochemical and morphologic study. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany. pp 122–129CrossRefGoogle Scholar
  43. Hurst, G., Heath, D. &Smith, P. (1987) Histological changes associated with ageing of the human carotid body. In “Chemoreceptors in Respiratory Control”, J.A. Ribeiro &D.J. Pallot, eds., Croom Helm, Kent, UK. pp 262–270CrossRefGoogle Scholar
  44. HeUstrom, S. &Hanbauer, I. (1981) Modification of the dopamine content in the rat carotid body by metacholine and hypoxia. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 220–230Google Scholar
  45. Heymans, C. (1951) Chemoreceptors and regulation of respiration. Acta. Physiol. Scand. 22:4–13CrossRefGoogle Scholar
  46. Hess, A., Mishra, J. &Sapru, H.N. (1981) Dopamine stimulation and preliminary studies on the presence and localisation of dopaminergic receptors in the rat carotid body. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 266–276Google Scholar
  47. Joels, N. &Neil, E. (1962) The action of high tensions of carbon monoxide on the carotid chemoreceptors. Arch Int. Pharmacodyn. Ther. 139:528–534PubMedGoogle Scholar
  48. Joels, N. &Neil, E. (1963) The excitation mechanism of the carotid body. Br. Med. Bull. 19:21–24PubMedGoogle Scholar
  49. Joels, N. &Neil, E. (1968) The idea of a sensory transmitter. In “Arterial Chemoreceptors.”, R.W. Torrance, ed.. Blackwell, Oxford, UK, pp 153–177Google Scholar
  50. Jordan, D., Donoghue, S., Felder, R.B. &Spyer, K.M. (1987) Central terminations of carotid body chemoreceptor afferents. In “Chemoreceptors in Respiratory Control”, J.A. Ribeiro &D.J. Pallot, eds., Croom Helm, Kent, UK. pp 29–38CrossRefGoogle Scholar
  51. Knoche, H. &Kienecker, E.-W. (1977a) Degenerative changes in rabbit carotid body following systematic denervation and preliminary results about the morphology of sinus nerve neuromas. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany. pp 25–29CrossRefGoogle Scholar
  52. Knoche, H. &Kienecker, E.-W. (1977b) Regeneration of nerves and nerve terminals in rabbit carotid body following carotid nerve sectioning and suturing. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany. pp 30–35Google Scholar
  53. Kreuser, F. (1976) Transmission of alveolar oxygen pressure oscillations. In “Morphology and Mechanisms of Chemoreceptors.” A.S. Paintal, ed., Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. pp. 176–190Google Scholar
  54. Krylov, S.S. &Anichkov, S.V. (1968) The effect of metabolic inhibitors on carotid chemoreceptors. In “Arterial Chemoreceptors.”, R.W. Torrance, ed., Blackwell, Oxford, UK, pp 103–113Google Scholar
  55. Lahiri, S. (1981) Dopamine and chemoreception in carotid and aortic bodies. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 277–288Google Scholar
  56. Lahiri, S. &DeLaney, R.G. (1976a) The nature of response of single chemoreceptor fibres of carotid body to changes in arterial PO2 and PCO2-H+. In “Morphology and Mechanisms of Chemoreceptors.” A.S. Paintal, ed., Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. pp. 18–26Google Scholar
  57. Lahiri, S. &DeLaney, R.G. (1976b) Effect of carbon monoxide on carotid chemoreceptor activity and ventilation. In “Morphology and Mechanisms of Chemoreceptors.” A.S. Paintal, ed., Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. pp. 340–344Google Scholar
  58. Lahiri, S. Smatresk, N., Pokorski, M., Barnard, P., Mokashi, A. &McGregor, K.H. (1983) Efferent inhibition of carotid body chemoreceptors in chronically hypoxic cats. Am. J. Physiol. 247:R24–R28Google Scholar
  59. Lahiri, S., Smatresk, N., Pokorski, M., Barnard, P., Mokashi, A. &McGregor, K.H. (1984) Dopaminergic efferent inhibition of carotid body chemoreception in chronically hypoxic cats. Am. J. Physiol. 245:R678–R683Google Scholar
  60. Leitner, L.-M. &Dejours, P. (1968) The speed of response of chemoreceptors. In “Arterial Chemoreceptors.”, R.W. Torrance, ed., Blackwell, Oxford, UK, pp 79–90Google Scholar
  61. Leitner, L.-M., Roumy, M. &Verna, A. (1981) Further studies on the cryodestruction of the rabbit carotid body. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 85–91Google Scholar
  62. Lubbers, D.W., Teckhaus, L. &Seidl, E. (1977) Capillary distances and oxygen supply to the specific tissue of the carotid body. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany, pp 62–68CrossRefGoogle Scholar
  63. McCloskey, D.I. (1968) Carbon dioxide and the carotid body. In “Arterial Chemoreceptors.”, R.W. Torrance, ed., Blackwell, Oxford, UK, pp 279–295Google Scholar
  64. McDonald, D.M. &Mitchell, R.A. (1975) A quantitative analysis of synaptic connections in the rat carotid body In “The Peripheral Arterial Chemoreceptors” M.J. Purves, ed., Cambridge University Press, London, UK, pp. 101–131Google Scholar
  65. McQueen, D.S. (1984) Effects of selective dopamine receptor agonists and antagonists on carotid body chemoreceptors. In “The Peripheral Arterial Chemoreceptors”, D.J.Pallot, ed., Croom Helm, London, UK.Google Scholar
  66. McQueen, D.S. &Kirby, G.C. (1987) Pharmacological studies on opioid receptors in the cat carotid body. In “Chemoreceptors in Respiratory Control”, J. A. Ribeiro &D J. Pallot, eds., Croom Helm, Kent, UK. pp 296–304CrossRefGoogle Scholar
  67. Mills, E. &Smith, P.G. (1981) Carotid sinus nerve function and reflexes after glomectomy. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 166–175Google Scholar
  68. Mir, A.K., Pallot, D.J. &Nahorski, S.R. (1984). Catecholamines: their receptors and cyclic AMP generating mechanisms in the carotid body. In “The Peripheral Arterial Chemoreceptors”, D.J.Pallot, ed., Croom Helm, London, UK. pp 311–324Google Scholar
  69. Mitchell, R.A. &McDonald, D.M. (1975) Adjustment of chemoreceptor sensitivity in the cat carotid body by reciprocal synapses. In “The Peripheral Arterial Chemoreceptors” M.J. Purves, ed., Cambridge University Press, London, UK, pp. 269–291Google Scholar
  70. Monteiro, E.C. &Ribeiro, J.S. (1987) Adenosine modulation of respiration mediated by carotid body chemoreceptors. In “Chemoreceptors in Respiratory Control”, J.A. Ribeiro &D.J. Pallot, eds., Croom Helm, Kent, UK. pp 314–321CrossRefGoogle Scholar
  71. Monti-Bloch, L. &Eyzaguirre, C. (1981) Different effects of putative neurotransmitters on cat and rabbit chemoreceptors. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 254–265Google Scholar
  72. Monti-Bloch, L., Stenaas, L.J. &Eyzaguirre, C. (1984) Induction of chemosensitivity in muscle nerve fibres by carotid body transplantation. In “The Peripheral Arterial Chemoreceptors”, D.J.Pallot, ed., Croom Helm, London, UK. pp 235–242Google Scholar
  73. Mulligan, E. &Lahiri, S. (1981) Mitochondrial oxidative metabolism and chemoreception in the carotid body. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 316–326Google Scholar
  74. Mulligan, E., Lahiri, S. &Storey, B.T. (1981) Carotid body O2 chemoreception and mitochondrial oxidative phosphorylation. J. Appl. Physiol. 51:438–446PubMedGoogle Scholar
  75. Neil, E. (1951) Chemoreceptor areas and chemoreceptor reflexes. Acta. Physiol. Scand. 22:54–65PubMedCrossRefGoogle Scholar
  76. Neil, E. &O’Regan, R.G. (1969a) Effects of sinus and aortic nerve efferents on arterial chemoreceptor function. J. Physiol. 200: 69P–71PPubMedGoogle Scholar
  77. Neil, E. &O’Regan, R.G. (1969b) Efferent and afferent impulse in the ‘intact’ sinus nerve. J. Physiol. 205:20P–21PPubMedGoogle Scholar
  78. O’Regan, R.G., (1975) The influences exerted by the centrifugal innervation of the carotid sinus nerve. In “The Peripheral Arterial Chemoreceptors” M.J. Purves, ed., Cambridge University Press, London, UK, pp. 221–240Google Scholar
  79. O’Regan, R.G. &Majcherczyk, S. (1983) Control of peripheral chemoreceptors by efferent nerves. In “Physiology of the Peripheral Arterial Chemoreceptors.”, H. Acker &R.G. O’Regan, eds., Elsevier, Amsterdam, pp. 257–298Google Scholar
  80. O’Regan, R.G. &Acker, H. (1984) Effects of sympathetic stimulation and catecholamines on extracellular calcium and potassium activities in the cat carotid body. In “The Peripheral Arterial Chemoreceptors”, DJ.PaUot, ed., Croom Helm, London, UK. pp 75–86Google Scholar
  81. O’Regan, R.G., Kennedy, M. &Przybyszewski, A.W. (1987) In “Chemoreceptors in Respiratory Control”, J.A. Ribeiro &D.J. Pallot, eds., Croom Helm, Kent, UK. pp 386–393CrossRefGoogle Scholar
  82. Pequignot, J.M., Tavitian, E., Boudet, C. &Peyrin, L. (1987) Reduction in dopaminergic activity in the rat carotid body after acute or chronic almitrine. In “Chemoreceptors in Respiratory Control”, J.A. Ribeiro &D.J. Pallot, eds., Croom Helm, Kent, UK. pp 378–385CrossRefGoogle Scholar
  83. Ponte, J.C.M.R. &Purves, M.J. (1975) On the speed of response of the chemoreceptors. In “The Peripheral Arterial Chemoreceptors” M.J. Purves, ed., Cambridge University Press, London, UK, pp. 357–371Google Scholar
  84. Purves, M.J. (1965) Oscillations of oxygen tension in arterial blood. J. Physiol. l76:7PGoogle Scholar
  85. Ribeiro, J.A. &McQueen, D.S. (1987) Chemoexcitation evoked by adenosine. Pharmacological characterisation of the receptor. In “Chemoreceptors in Respiratory Control”, J.A. Ribeiro &DJ. Pallot, eds., Croom Helm, Kent, UK. pp 305–313CrossRefGoogle Scholar
  86. Roumy, M. &Leitner, L.-M. (1977) Role of calcium ions in the mechanism of arterial chemoreceptor excitation. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany. pp 257–263CrossRefGoogle Scholar
  87. Rumsey, W.L., R. Iturriaga, D. Spergel, S. Lahiri &D.F. Wilson. (1991) Optical measurements of the dependence of chemoreception on oxygen pressure in the cat carotid body. Am. J. Physiol. 261(30):C614–C622PubMedGoogle Scholar
  88. Sampson, S.R. (1975) Pharmacology of feedback inhibition of carotid body chemoreceptors in the cat. In “The Peripheral Arterial Chemoreceptors” M.J. Purves, ed., Cambridge University Press, London, UK, pp.Google Scholar
  89. Sampson, S.R. &Biscoe, T.J. (1968) Rhythmical and non-rhythmical activity recorded from the central cut end of the sinus nerve. J. Physiol. 196:327–338PubMedGoogle Scholar
  90. Sampson, S.R. &Biscoe, T.J. (1970) Efferent control of the carotid body chemoreceptor. Experientia. 26:261–262PubMedCrossRefGoogle Scholar
  91. Smith, P., Hurst, G., Heath, D. &Drewe, R. (1987) The carotid bodies in a case of ventricular septal defect. In “Chemoreceptors in Respiratory Control”, J.A. Ribeiro &D.J. Pallot, eds., Croom Helm, Kent, UK. pp 254–261CrossRefGoogle Scholar
  92. Starlinger, H. (1977) Enzymes and inhibitors of the catecholamine metabolism in the cat carotid body. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany. pp 136–141CrossRefGoogle Scholar
  93. Starlinger, H &Acker, H. (1981) In vivo formation of octopamine in the cat carotid body and superior cervical ganglion under the influence of different respiratory gases. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 245–253Google Scholar
  94. Stenaas, L.J. Stenaas, S.S., Gonzalez, C. &Fidone, S.J. (1981) Analytical electron microscopy of granular vesicles in the carotid body of the normal and reserpinized cat. In “Arterial Chemoreceptors”, C. Belmonte, D.J. Pallot, H. Acker &S. Fidone, eds., Leicester University Press, Leicester, UK. pp 176–186Google Scholar
  95. Torrance, R.W. (1986) Prolegomena. In “Arterial Chemoreceptors.”, R.W. Torrance, ed.. Blackwell, Oxford, UK, pp 1–40Google Scholar
  96. von Euler, U.S., Liljestrand, G. &Zotterman, Y. (1939) Skand. Arch. Physiol. 83:132Google Scholar
  97. Wasserman, K. &Whipp, B.J. (1976) The carotid bodies and respiratory control in man. In “Morphology and Mechanisms of Chemoreceptors.” A.S. Paintal, ed., Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. pp. 156–175Google Scholar
  98. Weigelt, H. &Acker, H. (1977) Comparative measurements of tissue PO2 in the carotid body. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany. pp 244–249CrossRefGoogle Scholar
  99. Whalen, W.J. &Nair, P. (1976) Factors affecting the tissue PO2 in the carotid body of the cat. In “Morphology and Mechanisms of Chemoreceptors.” A.S. Paintal, ed., Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. pp. 91–102Google Scholar
  100. Whalen, W.J. &Nair, P. (1977) Factors affecting O2 consumption of the cat carotid body. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany. pp 233–239CrossRefGoogle Scholar
  101. Willshaw, P. (1975) Sinus nerve efferents as a link between central and peripheral chemoreceptors. In “The Peripheral Arterial Chemoreceptors” M.J. Purves, ed., Cambridge University Press, London, UK, pp. 253–267Google Scholar
  102. Woods, R.I. (1975) Penetration of horseradish peroxidase between all elements of the carotid body. In “The Peripheral Arterial Chemoreceptors” M.J. Purves, ed., Cambridge University Press, London, UK, pp. 195–205Google Scholar
  103. Yamamoto, W.S. (1960) Mathematical analysis of the time course of alveolar CO2 J. Appl. Physiol. 15:215–219Google Scholar
  104. Yamamoto, W.S. &Edwards, Mclver W. Jr. (1960) Homeostasis of carbon dioxide during intravenous infusion of carbon dioxide. J. Appl. Physiol. 15:807–818PubMedGoogle Scholar
  105. Zapata, P., Stenaas, L.J. &Eyzaguirre, C. (1977) Recovery of chemosensory function of regenerating carotid nerve fibres. In “Chemoreception in the Carotid Body”, H. Acker, S. Fidone, D. Pallot, C. Eyzaguirre, D.W. Lubbers &R. W Torrance, eds., Springer-Verlag, Berlin, Germany. pp 44–50CrossRefGoogle Scholar
  106. Zapata, P. Serani, A., Cardenas, H. &Lavados, M. (1984) Characterisation of dopaminoceptors in carotid body chemoreceptors. In “The Peripheral Arterial Chemoreceptors”, D.J.Pallot, ed., Croom Helm, London, UK. pp 335–344Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • R. G. O’Regan
    • 1
  • P. Nolan
    • 1
  1. 1.Department of Human Anatomy and PhysiologyUniversity CollegeDublin 2Ireland

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