Urolithiasis 2 pp 321-323 | Cite as

Role of Organic Matrix in the Formation and Growth of Calcium Oxalate Urinary Stones

  • S. R. Khan
  • R. L. Hackett
Chapter

Abstract

Organic matrix is an integral part of all urinary stones. It accounts for 2–3% of a stone’s total dry weight and its presence has long been thought essential for stone formation. It has been proposed that matrix plays an active architectonic role in the morphogenesis of urinary stones. To better understand the role of organic matrix in stone formation we studied calcium oxalate crystal-matrix association in: 1) crystalluria particles obtained from male hyperoxaluric rats and, 2) surgically removed human urinary stones.

Keywords

Stone Formation Organic Matrix Calcium Oxalate Urinary Stone Calcium Oxalate Crystal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    RL Hackett, PN Shevock, and SR Khan, Cell injury associated calcium oxalate crystalluria, J Urol 144: 1535 (1990).PubMedGoogle Scholar
  2. 2.
    SR Khan and RL Hackett, Crystal-matrix relationships in experimentally induced calcium oxalate monohydrate crystals, an ultrastructural study, Calcif Tissue Intl 41: 157 (1987).CrossRefGoogle Scholar
  3. 3.
    B Finlayson, SR Khan and RL Hackett, Mechanisms of stone formation — an overview, Scan Electr Microsc 3: 1419 (1984).Google Scholar
  4. 4.
    RM Morse and MI Resnick, A study of the incorporation of urinary macromolecules onto crystals of different mineral compositions, J Urol 141: 641 (1989).PubMedGoogle Scholar
  5. 5.
    SR Khan, PN Shevock and RL Hackett, Membrane associated crystallization of calcium oxalate in vitro, Calcif Tissue Intl 46: 116 (1990).CrossRefGoogle Scholar
  6. 6.
    AL Boskey, Current concepts of the physiology and biochemistry of calcification, Clin Orthopedics 157: 225 (1981).Google Scholar
  7. 7.
    SR Khan and RL Hackett, Retention of calcium oxalate crystals in renal tubules, Scan Microsc 5: 707 (1992).Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • S. R. Khan
    • 1
  • R. L. Hackett
    • 1
  1. 1.Department of Pathology, College of MedicineUniversity of FloridaGainesvilleUSA

Personalised recommendations